The Efficiency of Entry of Lymphoid Cells into Lymphoid and Non-Lymphoid Tissues

  • C. A. Ottaway
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Although there are many sites throughout the body where lymphocytes can leave the blood, migrating lymphoid cells appear to discriminate between different tissue destinations. Recirculating lymphocytes normally migrate through the lymph nodes, the spleen and the lymphoid tissues of the gut in preference to non-lymphoid tissues, but lymphoblasts are more likely to accumulate in various non-lymphoid tissues. This selective migration of lymphoid cells is taken to reflect the combination of fundamental differences in the probability that a given cell population will exit from the blood at different tissue sites and differences in the ability that the cells may have to interact with the micro-environment in which they have arrived. This paper concerns the potential interpretation of the time course of lymphoid cell migration to estimate the contribution of the uptake of cells to the accumulation observed within different tissues.


Cardiac Output Small Intestine Lymphoid Tissue Lymphoid Cell Label Cell 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • C. A. Ottaway
    • 1
  1. 1.Department of Medicine, St. Michael’s HospitalUniversity of TorontoTorontoCanada

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