Homing Pattern of Newly Formed Splenic Lymphocytes

  • Reinhard Pabst
  • Ernst Nowara
  • Karla Potschick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Pig and human spleens produce large numbers of lymphocytes and plasma cells (1,2). Many newly formed lymphocytes leave the spleen and home to different lymphoid and non-lymphoid organs (1). In mice the spleen was essential in producing memory cells for antibody production in the bone marrow after a booster injection (3). In the present study a technique for selective labeling of the pig spleen was used to study the fate of spleen-derived lymphocytes in other organs, to classify the emigrants and to localize them in lymphoid organs 1 to 4 d. after labeling the spleen exclusively. In a second experiment the rate of splenic lymphocyte production and immigration of newly formed lymphocytes was studied after a secondary response to i.v. sheep red blood cells.


Plasma Cell Lymphoid Cell Lymphoid Organ Splenic Lymphocyte Human Spleen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. Pabst, D. Munz, and F. Trepel. Cell. Immunol. 33:33 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    R. Pabst, and G. Reinecke. Scand. J. Haemat. 26:41 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    R. Benner, and A. van Oudenaren. Cell. Immunol. 19:167 (1975).PubMedCrossRefGoogle Scholar
  4. 4.
    R. Pabst, H. Reilmann, and P. Neuhaus. J. Immunol. Methods 33:23 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    A. Furguson. Gut 18:921 (1977).CrossRefGoogle Scholar
  6. 6.
    G. Koch, D.G. Osmond, M.H. Julius, and R. Benner. J. Immunol. 126:1447 (1981).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Reinhard Pabst
    • 1
  • Ernst Nowara
    • 1
  • Karla Potschick
    • 1
  1. 1.Center of AnatomyMedical School of HannoverHannover 61West Germany

Personalised recommendations