The Effect of Stimulated Macrophages on High Endothelial Venules and Germinal Centres in Lymph Nodes of Rat

  • H. R. Hendriks
  • H. A. B. v. Hemert
  • M. v. d. Heijden
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


Six weeks after interruption of afferent lymphatic vessels popliteal lymph nodes are severely depleted of macrophages (Mø) and have no germinal centres, lymphoblasts or plasma cells. The endothelial cells of the high endothelial venules (HEV) are flattened, have a poor affinity for pyronin, show an inactive nucleus and a paucity of protein synthesizing and secreting cell organelles. Lymphocytes in transit are absent in these venules (1, 2).


Lymph Node Plasma Cell Germinal Centre Popliteal Lymph Node Primary Follicle 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. R. Hendriks
    • 1
  • H. A. B. v. Hemert
    • 1
  • M. v. d. Heijden
    • 1
  1. 1.Department of Electron Microscopy, Medical FacultyFree UniversityAmsterdamThe Netherlands

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