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Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition

  • Eugene C. Butcher
  • Georg Kraal
  • Susan K. Stevens
  • Irving L. Weissman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

We have examined the organ specificity of migration of three major subpopulations of mature small lymphocytes in the mouse — B cells, the Ly-2- and Lyt-2+ T cells. It is shown that difference in the distribution of these lymphocyte classes between Peyer’s patches (PP’s) and peripheral lymph nodes (PN’s) are determined by selective recognition of endothelial determinants associated with high endothelial venules (HEV) in these organs. HEV are specialized venules that mediate lymphocyte exit from the blood into lymph nodes and Peyer’s patches. In addition, we report preliminary studies of the HEV-recognition specificity of gut-derived (mesenteric node) immunoblasts.

Keywords

Lymphoid Organ Mesenteric Node Distribution Index High Endothelial Venule Selective Recognition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Eugene C. Butcher
    • 1
  • Georg Kraal
    • 1
  • Susan K. Stevens
    • 1
  • Irving L. Weissman
    • 1
  1. 1.Department of PathologyStanford University Medical SchoolStanfordUSA

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