Organ-Specific Homing of B-Cell Hybridomas
In an adult animal, the physiological rule for red and white blood cells is continuous traffic (1). Conversely, the physiological rule for parenchymatous and endocrine organ cells is not to travel. Traffic of cells from organs is generally associated with malignant transformation. Malignant cells can leave primary tumor mass, enter the blood or the lymph circuits and are found to settle and proliferate in sites distant from the original tumor. Hence the acquisition of traffic properties by malignant cells could be a basic mechanism of metastatic dissemination. In the present work the metastatic capacity and homing characteristics of plasmacytoma-B lymphocyte hybridization was studied. The results indicated that somatic hybridization of non-metastatic tumor cells with cells which express high traffic poentialities (i.e. lymphocytes) conferred metastatic properties on a non-metastatic tumor cell and modified the homing properties of the parental tumor cell.
KeywordsSomatic Hybridization Experimental Metastasis Metastatic Dissemination Metastatic Pattern Metastatic Property
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- 1.de Souza, and M. Ecotaxis, in: “Immunopathology of Lymphomas”, R.A. Good, and J. Twomey, eds., Plenum Press, New York (1976).Google Scholar