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Organ-Specific Homing of B-Cell Hybridomas

  • P. De Baetselier
  • E. Gorelik
  • Z. Eshhar
  • Y. Ron
  • S. Katsav
  • M. Feldman
  • S. Segal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

In an adult animal, the physiological rule for red and white blood cells is continuous traffic (1). Conversely, the physiological rule for parenchymatous and endocrine organ cells is not to travel. Traffic of cells from organs is generally associated with malignant transformation. Malignant cells can leave primary tumor mass, enter the blood or the lymph circuits and are found to settle and proliferate in sites distant from the original tumor. Hence the acquisition of traffic properties by malignant cells could be a basic mechanism of metastatic dissemination. In the present work the metastatic capacity and homing characteristics of plasmacytoma-B lymphocyte hybridization was studied. The results indicated that somatic hybridization of non-metastatic tumor cells with cells which express high traffic poentialities (i.e. lymphocytes) conferred metastatic properties on a non-metastatic tumor cell and modified the homing properties of the parental tumor cell.

Keywords

Somatic Hybridization Experimental Metastasis Metastatic Dissemination Metastatic Pattern Metastatic Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    de Souza, and M. Ecotaxis, in: “Immunopathology of Lymphomas”, R.A. Good, and J. Twomey, eds., Plenum Press, New York (1976).Google Scholar
  2. 2.
    A.A. Freitas, and M. de Sousa. Eur. J. Immunol. 5:831 (1975).CrossRefGoogle Scholar
  3. 3.
    G. Poste, and G.L. Nicolson. Proc. Natl. Acad. Sci. USA 77:389 (1980).CrossRefGoogle Scholar
  4. 4.
    Y. Ron, P. de Baetselier, and S. Segal. Eur. J. Immunol. 11:94 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. De Baetselier
    • 1
    • 2
  • E. Gorelik
    • 1
    • 2
  • Z. Eshhar
    • 1
    • 2
  • Y. Ron
    • 1
    • 2
  • S. Katsav
    • 1
    • 2
  • M. Feldman
    • 1
    • 2
  • S. Segal
    • 1
    • 2
  1. 1.Instituut voor Moleculaire BiologieVUBSt-Genesius-RodeBelgium
  2. 2.Department of Cell Biology and Chemical ImmunologyWeizmann Institute of ScienceRehovotIsrael

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