Experimental Approaches to Lymphocyte Traffic: Pitfalls of the Tracer Sample Method

  • W. L. Ford
  • M. E. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The recirculation of lymphocytes between the blood and the tissues can be regarded as occurring in four stages -
  1. 1)

    Selective migration from the blood into particular tissues. This is governed by an unknown number of specific interactions between lymphocytes and vascular endothelium.

  2. 2)

    Segregation of B and T lymphocytes into distinct compartments of peripheral lymphoid tissue.

  3. 3)

    Migration of lymphocytes through interstitial and lymphatic channels to return to the blood.

  4. 4)

    Distribution by the bloodstream to different organs.



Mouse Lymph Node Thoracic Duct Selective Migration Anatomical Compartment Peripheral Lymphoid Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H.B. Stamper, and J.J. Woodruff. J. Exp. Med. 144:828 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    J.L. Gowans, and E.J. Knight. Proc. Roy. Soc. B. 159:257 (1964).CrossRefGoogle Scholar
  3. 3.
    W.L. Ford, in: “Handbook of Experimental Immunology,” D.M. Weir, ed., Blackwell, Oxford (1978).Google Scholar
  4. 4.
    W.L. Ford, M.E. Smith, and P. Andrews, in: “Cell-cell Recognition,” A.S.G. Curtis, ed., Cambridge University Press (1978).Google Scholar
  5. 5.
    B.M. Hall, S. Dorsch, B.J. Roser. J. Exp. Med. 148:890 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    W. Chin, and J.B. Hay. Gastroenterology, in press (1981).Google Scholar
  7. 7.
    M.E. Smith, A.F. Martin, and W.L. Ford, in: “Essays on the Anatomy and Physiology of Lymphoid Tissue,” Z. Trnka and R.N.P. Cahill, eds., Karger, Basel (1980).Google Scholar
  8. 8.
    W.L. Ford, M. Sedgley, S.M. Sparshott, and M.E. Smith. Cell Tissue Kinet. 9:351 (1976).PubMedGoogle Scholar
  9. 9.
    J. Cox, and W.L. Ford. To be published.Google Scholar
  10. 10.
    E.M. Lance, and R.N. Taub. Nature 211:841 (1969).CrossRefGoogle Scholar
  11. 11.
    W.L. Ford, and S.J. Simmonds. Cell Tissue Kinet. 5:175 (1972).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. L. Ford
    • 1
  • M. E. Smith
    • 1
  1. 1.Department of Experimental PathologyUniversity Medical SchoolManchesterUK

Personalised recommendations