Lymphoid Antigens on Non-Lymphoid Factor-Dependent Haemopoietic Cell Lines
The current concept of haemopoietic cell renewal is that the terminally differentiated cells arise from division and maturation of lineage-specific committed progenitors. These progenitors have a limited capacity for self-renewal and are defined by their ability to form lineage-restricted clones in vitro in the presence of specific growth/differentiation factors. For example, Colony Stimulating Factor (GM-CSF) is a requisite for both limited self-renewal and differentiation of committed precursors (CFU-C) of cells of the granulocyte/macrophage series (1). Effective unlimited capacity for self-renewal is considered restricted to “pluripotent” stem cells (CFU-S), which by differentiation “feed” into the committed precursor pools (2–4). However, a number of cell types considered close to terminal differentiation can be induced to proliferate extensively, in some cases indefinitely, as demonstrated by the continuous culture of T-cell lines using T-cell growth factor (IL-2) (5–7).
KeywordsHaemopoietic Cell Agar Coloni Dependent Cell Line Lymphoid Antigen Infected Bone Marrow
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