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Lymphoid Antigens on Non-Lymphoid Factor-Dependent Haemopoietic Cell Lines

  • J. M. Garland
  • T. M. Dexter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

The current concept of haemopoietic cell renewal is that the terminally differentiated cells arise from division and maturation of lineage-specific committed progenitors. These progenitors have a limited capacity for self-renewal and are defined by their ability to form lineage-restricted clones in vitro in the presence of specific growth/differentiation factors. For example, Colony Stimulating Factor (GM-CSF) is a requisite for both limited self-renewal and differentiation of committed precursors (CFU-C) of cells of the granulocyte/macrophage series (1). Effective unlimited capacity for self-renewal is considered restricted to “pluripotent” stem cells (CFU-S), which by differentiation “feed” into the committed precursor pools (2–4). However, a number of cell types considered close to terminal differentiation can be induced to proliferate extensively, in some cases indefinitely, as demonstrated by the continuous culture of T-cell lines using T-cell growth factor (IL-2) (5–7).

Keywords

Haemopoietic Cell Agar Coloni Dependent Cell Line Lymphoid Antigen Infected Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. M. Garland
    • 1
  • T. M. Dexter
    • 1
  1. 1.The Paterson LaboratoriesChristie Hospital and Holt Radium InstituteWithington, ManchesterEngland

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