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Differences in In Vivo Functional Capacities of Avian Precursor B and T Cells Following In Vitro Incubation

  • W. T. Weber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Results of previous experiments in this laboratory have pointed to the possible existence of separate lineages of precursor T (PT) and precursor B (PB) cells in avian embryonic hematopoietic tissues (1,2). In view of these findings we have suggested that the bursa and thymus are not populated by multipotential stem cells (3,4), but rather, by cells already differentiated to the level of a committed PT and PB cell respectively. With this as a working model, we were interested in determining whether the postulated precursor cell populations displayed differential sensitivity to a variety of experimental procedures, resulting in a possible elimination of one of the two postulated cell types.

Keywords

Donor Cell Suppressor Cell Donor Type Multipotential Stem Cell Hematopoietic Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W.T. Weber, and R. Mausner, in: “Avian Immunology”, A.A. Benedict, ed., Plenum Publishing Corp., New York (1977).Google Scholar
  2. 2.
    W.T. Weber, and L.M. Foglia. Cell. Immunology 52:84 (1980).CrossRefGoogle Scholar
  3. 3.
    M.A.S. Moore, and J.J.T. Owen. Nature 215:1081 (1967).PubMedCrossRefGoogle Scholar
  4. 4.
    N.M. Le Douarin, E. Houssaint, and F. Jotereau, in: “Avian Immunology”, A.A. Benedict, ed., Plenum Publishing Corp., New York (1977).Google Scholar
  5. 5.
    W.T. Weber. Transplant. Rev. 24:113 (1975).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. T. Weber
    • 1
  1. 1.Department of PathobiologyUniversity of PennsylvaniaPhiladelphiaUSA

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