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Pre B Cell Leukaemia in the Rat

  • J. Rozing
  • L. M. B. Vaessen
  • L. Faber
  • M. van Oven
  • L. de Vries-Box
  • B. de Jong
  • P. Nieuwenhuis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Recently a case of spontaneous B cell leukaemia has been reported in mice (1). In rats, a transplantable lymphoid leukaemia, which arose originally in a rat undergoing chronic internal beta-irradiation of the spleen, has been described by Dibley et al. (2,3). Based on the absence of surface immunoglobulin molecules and Fcreceptors, and the presence of the Thy-1 determination the surface of the leukaeraic cells, as well as on the appearance of pyroninophilic lymphoblasts in T dependent lymphoid areas after inoculation of syngeneic recipients with tumour cells, this malignancy has been designated as a T cell leukaemia (2). We report here some of the characteristics of a pre B cell leukaemia derived from the successfully transferred in (AOxBN)F1 hybrid rats.

Keywords

Cell Leukaemia Spleen Cell White Pulp Leukaemic Cell Dextran Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • J. Rozing
    • 1
  • L. M. B. Vaessen
    • 1
  • L. Faber
    • 2
  • M. van Oven
    • 2
  • L. de Vries-Box
    • 2
  • B. de Jong
    • 3
  • P. Nieuwenhuis
    • 2
  1. 1.Dept. of Internal Medicine IErasmus University RotterdamRotterdamThe Netherlands
  2. 2.Dept. of HistologyUniversity of GroningenGroningenThe Netherlands
  3. 3.Dept. AnthropogeneticsUniversity of GroningenGroningenThe Netherlands

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