Pre B Cell Leukaemia in the Rat
Recently a case of spontaneous B cell leukaemia has been reported in mice (1). In rats, a transplantable lymphoid leukaemia, which arose originally in a rat undergoing chronic internal beta-irradiation of the spleen, has been described by Dibley et al. (2,3). Based on the absence of surface immunoglobulin molecules and Fcreceptors, and the presence of the Thy-1 determination the surface of the leukaeraic cells, as well as on the appearance of pyroninophilic lymphoblasts in T dependent lymphoid areas after inoculation of syngeneic recipients with tumour cells, this malignancy has been designated as a T cell leukaemia (2). We report here some of the characteristics of a pre B cell leukaemia derived from the successfully transferred in (AOxBN)F1 hybrid rats.
KeywordsCell Leukaemia Spleen Cell White Pulp Leukaemic Cell Dextran Sulphate
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- 5.J. Rozing, and L.M.B. Vaessen. Transpl. Proc. 11:1657 (1979).Google Scholar
- 6.L.M.B. Vaessen, L.D.F. Lameljer, C.B. Carpenter, D.V. Cramer, and J. Rozing. Transpl. Proc. 11:1565 (1979).Google Scholar
- 9.D.G. Osmond, in: “Stem Cells of Renewing Cell Populations”, p. 195, A.B. Cairnie, P.K. Lala, and D.G. Osmond, eds. (1976).Google Scholar