The Role of Bursal Microenvironment in the Maturation of B Cells
At hatching the bursa of Fabricius in chicken contains functionally immature B cells, so called bursal stem cells. These cells are characterized by strict bursa dependence. They need a possibility to home into and proliferate in the bursa in order to express their whole functional repertoire. Bursa cell transplantation into cyclophosphamide (CY) induced immunodeficient recipients provides a good model to study microenvironmental effects on B cell maturation. Our earlier results indicated that bursal stem cells undergo full maturation in an allogeneic environment but do not collaborate with host derived T cells (1–4). These findings raised a doubt about the influence of the maturation environment on B cells’ cooperation preferences. Recently Katz et al. and Gorczynski et al. reported that not only T cells but also B cells would preferentially collaborate with the cells exhibiting the major histocompatibility determinants encountered in the differentiation environment (5,6). In the present work we have approached this problem by studying whether (PxV)F1 bursal stem cells maturing in a parental host would develop collaboration preference with other lymphoid cells of that environment.
KeywordsLine Versus Parental Host Brucella Abortus Full Maturation Maturation Environment
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