Maturity of Precursor Cells for Germinal Centers
According to the cells localizing directly in germinal centers the direct precursor of germinal center cells is a large cell both in the chicken, where low density (larger) bursa cells show a better localization in germinal centers than do higher density (smaller) bursa cells,1 and in the rabbit where the larger cells of lower density of appendix localize in germinal centers whereas smaller cells localize in the corona of follicles.2 However, we cannot conclude from such findings whether the maturity of the donor cells is the determining factor or whether these findings mean only that blast B cells have a different localization pattern from small B cells. The other evidence presented at this meeting, concerning surface Ig markers (α and γ) of peanut agglutinin positive B cells from peripheral lymphoid tissue, representing primarily germinal center cells,3,4,5 suggests a greater maturity of these cells rather than an immature precursor nature, since these would be expected to bear μ. If, however, switching from μ to other Ig isotypes occurs through interaction between sister chromatids during mitosis, this process might occur in germinal centers and could possibly take place within the first mitosis of cells entering these structures.
KeywordsSister Chromatid Mouse Lymph Node Great Maturity Peanut Agglutinin Bearing Cell
Unable to display preview. Download preview PDF.
- 2.D. Opstelten, G.J. Deenen, L. Bos, and P. Nieuwenhuis, Localization patterns of germinal center cell subsets differing in density and in sedimentation velocity, this symposium.Google Scholar
- 4.E.C. Butcher, R.A. Reichert, R.V. Rouse, R. Coffman, C. Nottenburg, and I.L. Weissman, Surface phenotype and migratory capability of Peyer’s patch germinal center cells, this symposium.Google Scholar
- 5.M.L. Rose, F.J. Booth, and J. Habeshaw, Separation and characteristics of germinal centre lymphocytes using peanut lectin binding, this symposium.Google Scholar
- 6.E.B. Jacobson, Y. Baine, Y.-W. Chen, P.J. Dhabar, T. Flotte, M.J. O’Neil, B. Pernis, G.w. Siskind, P. Tonda, and G.J. Thorbecke, Physiology of IgD. I. Compensatory phenomena in β-lymphocyte activation in mice treated with anti-IgD antibodies, J. Exp. Med., in press (1981).Google Scholar