Isolation and Properties of Spleen Follicular Dendritic Cells

  • John H. Humphrey
  • Deirdre Grennan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


There are several excellent electron microscopic studies of follicular dendritic cells (f.d.c.) in germinal centres, identified by their capacity to bind detectable antigen-antibody complexes at their surface (1, 2, 3, 4). They show that f.d.c. have an irregularly shaped nucleus with relatively little perinuclear cytoplasm, but they have long branching cytoplasmic extensions lacking lysosomes or any indication of phagocytosis.


Germinal Centre Multinucleate Cell Follicular Dendritic Cell Post Capillary Venule Perinuclear Cytoplasm 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • John H. Humphrey
    • 1
  • Deirdre Grennan
    • 1
  1. 1.Department of Immunology, Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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