Disparity between Humoral Antibody Formation and Proliferative Reactions in Lymph Nodes: C57L/J vs. Haired and Hairless HRS/J MICE
The three genotypes of HRS/J strain mice, +/+, hr/+, and hr/hr, differ only with respect to the mutant locus on chromosome 14 (hr for “hairless”) or a region closely linked to it1. Homozygous hairless” (hr/hr) mice develop a severe thymic atrophy which sets in at the age of approximately 6 months, concomitant with deficient immune responses to certain antigens2. The derangement underlying the immunodeficiency of mice which carry the hr gene includes a disproportionate distribution of T-cell subpopulations: a decrease in the number of Ly-1 and a parallel increase in the number of Ly-123 cells became noticeable in hr/hr mice at the age of 3 months and in hr/+ animals between 7 to 10 months of age3.
KeywordsGerminal Center Tetanus Toxoid Popliteal Lymph Node Aluminum Phosphate Germinal Center Formation
Unable to display preview. Download preview PDF.
- 1.L.D. Shultz, Mutant genes affecting development of the immune system: Mouse, in: “Inbred and Genetically Defined Strains of Laboratory Animals”, part I, P.I. Altman and D.D. Katz, eds., FASEB, Bethesda (1979).Google Scholar
- 4.G.J. Thorbecke and P. Lerman, Germinal centers and their role in immune response. Adv. Exp. Med. Biol. 73A:83 (1976).Google Scholar
- 5.N.A. Gastkemper, A.S. Wubbena and P. Nieuwenhuis, Germinal centres and the B-cell system: A search for the germinal centre precursor in the rat, in: “Function and Structure of the Immune System”, W. Müller-Ruchholtz and H.K. Müller-Hermelink, eds., Plenum Press, New York/London (1979).Google Scholar
- 6.A.B. Reske-Kunz, M.P. Scheid, M. de Sousa and E.A. Boyse, Correlation of immunogenetic and histological chenges in immunodeficient mutant hr/hr mice, in: see reference 5.Google Scholar