The Proliferative Activity of Antibody Forming Cells in the Mouse Bone Marrow

  • G. Koch
  • B. D. Lok
  • R. Benner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The proliferative activity of antibody-forming cells was studied in the bone marrow of mice immunized with either sheep erythrocytes (SRBC), TNP-LPS or DNP-Ficoll. Peak proliferative activity was found during the first few days of the response. Elimination of the proliferating cells in this period caused a profound and long-lasting suppression of the antibody formation in the marrow.


Bone Marrow Proliferative Activity Mouse Bone Marrow Primary Immunization Booster Injection 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. Koch
    • 1
  • B. D. Lok
    • 1
  • R. Benner
    • 1
  1. 1.Dept. of Cell Biology & GeneticsErasmus UniversityRotterdamThe Netherlands

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