The Role of T Cells in B Cell Priming and Germinal Centre Development

Klaus, G. G. B.; Kunkl, Annalisa

doi:10.1007/978-1-4684-9066-4_103

G. G. B. Klaus³ &
Annalisa Kunkl³^nAff4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 149))

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Abstract

The concept that germinal centres are sites of B memory (B_M) cell proliferation is well-documented. Our own contribution to this area has been to provide evidence which suggests that the stimulus for germinal centre development is the deposition of antigen-antibody (Ag-Ab)-C3 complexes on follicular dendritic cells in lymphoid follicles. This conclusion is largely based on the capacity of minute doses of performed Ag-Ab complexes to induce the rapid appearance of B_M cells, and germinal centres, in mice (reviewed in 1).

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Author information

Annalisa Kunkl
Present address: Cattedra di Immunologie, Universita di Genova, V.le Benedetto XV, 10 16132, Genova, Italy

Authors and Affiliations

Division of Immunology, National Institute for Medical Research, Mill Hill, London NW7, UK
G. G. B. Klaus & Annalisa Kunkl

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G. G. B. Klaus
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Annalisa Kunkl
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Editors and Affiliations

University of Groningen, Groningen, The Netherlands
Paul Nieuwenhuis & A. A. van den Broek &
NCI-Frederick Cancer Research Facility, Frederick, Maryland, USA
M. G. Hanna Jr.

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Klaus, G.G.B., Kunkl, A. (1982). The Role of T Cells in B Cell Priming and Germinal Centre Development. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_103

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DOI: https://doi.org/10.1007/978-1-4684-9066-4_103
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-9068-8
Online ISBN: 978-1-4684-9066-4
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