The Role of T Cells in B Cell Priming and Germinal Centre Development

  • G. G. B. Klaus
  • Annalisa Kunkl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The concept that germinal centres are sites of B memory (BM) cell proliferation is well-documented. Our own contribution to this area has been to provide evidence which suggests that the stimulus for germinal centre development is the deposition of antigen-antibody (Ag-Ab)-C3 complexes on follicular dendritic cells in lymphoid follicles. This conclusion is largely based on the capacity of minute doses of performed Ag-Ab complexes to induce the rapid appearance of BM cells, and germinal centres, in mice (reviewed in 1).


Nude Mouse Cell Priming Normal Mouse Lymphoid Follicle Follicular Dendritic Cell 


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  1. 1.
    G.G.B. Kalus, J.H. Humphrey, A. Kunkl, and D.W. Dongworth. Immunol. Revs. 53:3 (1980).CrossRefGoogle Scholar
  2. 2.
    G.E. Roelants, and B.A. Askonas. Nature New Biol. 239:63 (1972).PubMedGoogle Scholar
  3. 3.
    T. Diamantstein, and E. Blitstein-Willinger. Eur. J. Immunol. 4:830 (1974).CrossRefGoogle Scholar
  4. 4.
    G.J. Thorbecke, and S.P. Lerman. Adv. Exp. Biol. 73A:83 (1976).Google Scholar
  5. 5.
    J.W. Schrader. J. Immunol. 114:1665 (1975).PubMedGoogle Scholar
  6. 6.
    G.G.B. Klaus. Immunology Today 2:83 (1981).CrossRefGoogle Scholar
  7. 7.
    A. Kunkl, and G.G.B. Klaus. J. Immunol. 125:2526 (1980).PubMedGoogle Scholar
  8. 8.
    D.G. Sieckmann, I. Scher, R. Asofsky, D.E. Mosier, and W.E. Paul. J. Exp. Med. 148:1628 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    J.C. Brown, D.G. de Jesus, and E.J. Holborow. Nature 228:367 (1970).PubMedCrossRefGoogle Scholar
  10. 10.
    J. Mitchell, J. Pye, M.C. Holmes, and G.J.V. Nossal. J. Exp. Biol. Med. Sci. 50:637 (1972).CrossRefGoogle Scholar
  11. 11.
    H.R. MacDonald, R.K. Lees, B. Sordat, P. Zaech, J.L. Maryanski, and C. Bron. J. Immunol. 126:865 (1981).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • G. G. B. Klaus
    • 1
  • Annalisa Kunkl
    • 1
  1. 1.Division of ImmunologyNational Institute for Medical ResearchLondon NW7UK

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