Immune Response Regulation
During the last years we have learned about cell interactions required to generate effector cells during immune responses. Our knowledge of the cell interactions leading to the production of antibody-forming cells, cells mediating delayed-type hypersensitivity (DTH) reactions and cytotoxic T lymphocytes is advanced because we have been able to study clones of these cell types. Our knowledge of cell interactions leading to generation of T suppressor cells is not quite as detailed; complicated circuits involving three or four discrete steps are invoked by recent experiments. We do not know whether different cell lineages are involved in each step. In the following I would like to concentrate first on aspects concerned with the induction of nonsuppressive effector cells and then discuss some experiments concerned with suppressor cells.
KeywordsEffector Cell Helper Cell Suppressor Cell Soluble Antigen Immune Response Regulation
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