Advertisement

Developmental Aspects of T-Suppressor Cells Induced by Hapten-Carrier Conjugates

  • M. Ritterband
  • A. Globerson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)

Abstract

Immunoregulation is attributed, at least in part, to suppressor cells of the T compartment (1). In this respect, it has been suggested that suppressor cells emerging in ontogeny may play a role in establishment of tolerance to self (2,3). By the same token the possibility that failure of immunological functions in senescence may be brought about by alterations in specific suppressor mechanisms has been considered (4,5). Accordingly, lowered avidity and affinity of antibodies produced in aging seem to be causally related to the status of suppressor cells (6,7). On the other hand, the mechanisms underlying lowered specificity of the antibodies (8) and of effector T cell functions (9) in aging have not yet been elucidated. One may thus wonder as to whether the reduced specificity is actually manifested at the suppressor level.

Keywords

Spleen Cell Suppressor Cell Congenic Strain Weizmann Institute Nonspecific Suppression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R.K. Gershon. Contemp. Topics. Immunobiol. 3:1 (1974).CrossRefGoogle Scholar
  2. 2.
    T. Umiel, in: “Developmental Immunobiology”, J.B. Solomon and Y.D. Horton, eds., p. 323, Elsevier/North-Holland Biomed. Press., Amsterdam (1977).Google Scholar
  3. 3.
    T. Umiel, H. Rabinowich, and A. Globerson, in: “Developmental and Comparative Immunology”, J.B. Solomon, ed., p. 423, Pergamon Press (1981).Google Scholar
  4. 4.
    R.L. Walford. Fed. Proc. 33:2020 (1974).PubMedGoogle Scholar
  5. 5.
    R.K. Gershon, and CM. Metzler, in: “Comprehensive Immunology”, T Makinodan and E. Yunis, eds., Vol. I: Immunology and Aging, p. 103 (1977).Google Scholar
  6. 6.
    G. Doria, C. Mancini, G. Di Felice, and L. Adorini, in: Developmental and Comparative Immunology, J.B. Solomon, ed. , p. 453, Pergamon Press (1981).Google Scholar
  7. 7.
    E.A. Goidl, J.B. Innes, and M.E. Weksler. J. Exp. Med. 144:1037 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    D. Naor, B. Bonavida, and R.L. Walford. J. Immunol. 117: 2204 (1976).PubMedGoogle Scholar
  9. 9.
    A.M. Kruisbeek, and Steinmeier. J. Immunol. 125:858 (1980).PubMedGoogle Scholar
  10. 10.
    A. Bernstein, and A. Globerson. Eur. J. Immunol. 7:598 (1977).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Ritterband, A. Bernstein, and A. Globerson. Israel J. Med. Sci. 15:189 (1979).Google Scholar
  12. 12.
    H. Rabinovich, T. Umiel, Y. Reisner, N. Sharon, and A. Globerson. Cell. Immunol. 47:347 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    A. Globerson, L. Abel, and T Umiel. Mech. Aging Dev. (1981) in press.Google Scholar
  14. 14.
    G. Berke, K.A. Sullivan, and B. Amos. J. Exp. Med. 135: 1334 (1972).PubMedCrossRefGoogle Scholar
  15. 15.
    R.I. Mishell, and R.W. Dutton. J. Exp. Med. 126:423 (1967).PubMedCrossRefGoogle Scholar
  16. 16.
    D. Friedman, and A. Globerson. Mech. Aging Dev. 7:289 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • M. Ritterband
    • 1
  • A. Globerson
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

Personalised recommendations