Marginal Zones: The Largest B Cell Compartment of the Rat Spleen

  • D. S. Kumararatne
  • I. C. M. MacLennan
  • H. Bazin
  • D. Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 149)


The marginal zone of rat spleens consist of a massive sinusoidal network fed by the terminal branches of the splenic artery (1,2). Within the zone are large numbers of intermediate sized lymphocytes. In this report we summarize the characteristics of these cells and compare them with the lymphocytes found in the inner small lymphocytic zones of the splenic white pulp.


Marginal Zone White Pulp Recirculate Cell Splenic White Pulp Marginal Zone Cell 
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  1. 1.
    T. Snook. Am J. Anat. 87:31 (1950).PubMedCrossRefGoogle Scholar
  2. 2.
    A.E. Dubreuil, P.G. Herman, N. Tilney, and H.Z. Millins. Am. J. Roentgehol Radium. Ther. Nuc. Med. 123:427 (1975).Google Scholar
  3. 3.
    J.C. Howard, S.V. Hunt, and J.L. Gowans. J. Exp. Med. 135:200 (1972).PubMedCrossRefGoogle Scholar
  4. 4.
    P. Nieuwenhuis, and W.L. Ford. Cell. Immunol. 23:254 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    D.S. Kumararatne, A.C. Campbell, I.C.M. MacLennan, in: “Immunopharmacological Effects of Radiation Therapy”, J.B. Dubois, B. Serron, and C. Rosenfeld, eds. EORTL, Vol. 8, p. 93, Raven Press, New York (1980).Google Scholar
  6. 6.
    D.S. Kumararatne, H. Bazin, I.C.M. MacLennan. Eur. J. Immunol. (1981) in press.Google Scholar
  7. 7.
    H. Stein, A. Bonk, G. Tolksdorf, K. Lennert, H. Rodt, and J. Gerdes. J. Histochem. and Cytochem. 28:746 (1980).CrossRefGoogle Scholar
  8. 8.
    N.A. Gastkemper, A.S. Wubbena, and P. Nieuwenhuis. Adv. in Exp. Med. Biol. 114:43 (1978).Google Scholar
  9. 9.
    W.L. Ford. Br. J. Exp. Path. 49:502 (1968).Google Scholar
  10. 10.
    J.L. Press, N.R. Klinman, C Henry, L. Wolfsy, L.D. Terry, H.O. McDevit, in: “Membrane Receptors of Lymphocytes”, M. Seligmann, J.L. Preud’homme, and F.M. Kourilsky, eds. North Holland Press, Amsterdam.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. S. Kumararatne
    • 1
  • I. C. M. MacLennan
    • 1
  • H. Bazin
    • 2
  • D. Gray
    • 1
  1. 1.Department of ImmunologyUniversity of BirminghamBirminghamUK
  2. 2.Experimental Immunology UnitUniversity of LouvainBrusselsBelgium

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