Quantitative Structure-Activity Relationship Analysis of Natural Products: Phototoxic Thiophenes

  • Robin J. Marles
  • J. Thor Arnason
  • R. Lilia Compadre
  • Cesar M. Compadre
  • Chantal Soucy-Breau
  • Bella Mehta
  • Peter Morand
  • Robert W. Redmond
  • J. C. Scaiano
Part of the Recent Advances in Phytochemistry book series (RAPT, volume 25)


The wide diversity of secondary metabolites known to exist throughout the plant kingdom has been partially attributed to plant-pest coevolution,1,2 although aspects of the process remain controversial.3 It is also known that fungal infections can elicit the production and accumulation of toxic plant secondary metabolites.4 The elaborate design of chemical defences in plants can involve mixtures of related structures in one biosynthetic class or multiple lines of chemical defence in a single plant species.5 For example, Chrysanthemum spp. contain several phototoxic thiophenes and acetylenes, cytotoxic sesquiterpene lactones, and insecticidal Pyrethrins and isobutylamides.6


Partition Coefficient Singlet Oxygen Brine Shrimp Mosquito Larva Sesquiterpene Lactone 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Robin J. Marles
    • 1
  • J. Thor Arnason
    • 1
  • R. Lilia Compadre
    • 2
  • Cesar M. Compadre
    • 2
  • Chantal Soucy-Breau
    • 3
  • Bella Mehta
    • 3
  • Peter Morand
    • 3
  • Robert W. Redmond
    • 4
  • J. C. Scaiano
    • 4
  1. 1.Ottawa-Carleton Institute of BiologyUniversity of OttawaOttawaCanada
  2. 2.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Ottawa-Carleton Institute of ChemistryUniversity of OttawaOttawaCanada
  4. 4.Steacie Institute for Molecular SciencesNational Research CouncilOttawaCanada

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