The Effects of 4-Nitroquinoline-N-Oxide (4NQO) at Different Stages of Triturus Limb Regeneration
The concept that an inverse association may exist between the regenerative capacity of an animal and its susceptibility to neoplasia is old (Waddington, 1935; Prehn, 1971) but even in our days it remains popular (Tsonis, 1987). There is a considerable degree of contradiction in this field since various studies have revealed that some carcinogenic substances do not affect, whereas others have shown that carcinogens arrest regeneration (Tsonis, 1983).
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