Digit Regeneration in Triturus Cristatus after Pattern Transforming Interventions

  • S. Koussoulakos
  • V. Kiortsis
Part of the NATO ASI Series book series (NSSA, volume 172)


Experimental interventions during limb regeneration in Anurans (Maden 1981) and Urodele amphibians (Wallace, 1981) have been widely exploited for a better understanding of the rules governing the reappearance of the structures removed. It has been suggested and experimentally supported that limb morphogenesis is dictated at every level by a system of positional codings operating along the three conventional axes of the limb, namely the proximodistal (PD), the anteroposterior (AP) and the dorsoventral (DV). These positional codings are thought to be a property of the individual cells and constitute their posititional value, which specifies their fate during development (Wolpert, 1971). The cells of a developing or regenerating urodele amphibian limb become endowed with these codings according to the position they occupy in the growing structure. At each limb level the cells are thought to possess the same PD positional information, whereas there are considerable variations along the transverse axes (Bryant and Gardiner, this volume).


Limb Regeneration Digit Versus Vertebrate Limb Digit Regeneration Positional Codings 
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  1. Alberch P. and Gale E., 1983, Size dependence during the development of the amphibian foot. Colchicine-induced digital loss and reduction, J. Embryol. exp. Morphol., 76:177–197.PubMedGoogle Scholar
  2. Bonnet C., 1777, Observations sur la Physique. 1. Mem. Tome X, 388–405, 2. Mem. Tome XIII, 1–18.Google Scholar
  3. Bryant S. and Gardiner D., 1988, Position dependent growth and pattern formation in limb regeneration, (This volume).Google Scholar
  4. Maden M., 1981, Experiments on anuran limb buds and their significance for principles of vertebrate limb development, J. Embryol. exp. Morphol., 63:243–265.PubMedGoogle Scholar
  5. Maden M., 1983, The effect of vitamin A on the regenerating axolotl limb, J. Embryol. exp. Morphol., 77:273–295.PubMedGoogle Scholar
  6. Salpeter M. and Singer M., 1960, Differentiation of the sub-microscopic adepidermal membrane during limb regeneration in adult Triturus, including a note on the use of the term “basement membrane”, Anat. Rec., 136:27–40.PubMedCrossRefGoogle Scholar
  7. Shubin N.H. and Alberch P., 1986, A morphogenetic approach to the origin and basic organization of the tetrapod limb, Evol. Biol., 20:319–387.CrossRefGoogle Scholar
  8. Smith R.A., 1978, Digit regeneration in the amphibian Triturus cristatus, J. Embryol. exp. Morphol., 44:105–112.PubMedGoogle Scholar
  9. Stock B.G. and Bryant S., 1981, Studies of digit regeneration and their implications for theories of development and evolution of vertebrate limbs, J. Exp. Zool., 216: 423–433.PubMedCrossRefGoogle Scholar
  10. Tassava R., 1988, Limb regeneration in newts: an immunological search for developmentally significant antigens. in: “Regeneration and Development”, S. Inoue, ed., Okada, Maebashi, Japan.Google Scholar
  11. Tornier G., 1896/1897. Hyperdaktylie, Regeneration und Vererbung, Arch. Entw. Mech. 3 und 4.Google Scholar
  12. Wallace H., 1981, “Vertebrate limb regeneration”, Wiley, Chichester.Google Scholar
  13. Wolpert L., 1971, Positional information and pattern formation, Curr. Top. Dev. Biol., 6:183–224.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • S. Koussoulakos
    • 1
  • V. Kiortsis
    • 1
  1. 1.Zoological LaboratoryUniversity of AthensAthensGreece

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