Digit Regeneration in Triturus Cristatus after Pattern Transforming Interventions
Experimental interventions during limb regeneration in Anurans (Maden 1981) and Urodele amphibians (Wallace, 1981) have been widely exploited for a better understanding of the rules governing the reappearance of the structures removed. It has been suggested and experimentally supported that limb morphogenesis is dictated at every level by a system of positional codings operating along the three conventional axes of the limb, namely the proximodistal (PD), the anteroposterior (AP) and the dorsoventral (DV). These positional codings are thought to be a property of the individual cells and constitute their posititional value, which specifies their fate during development (Wolpert, 1971). The cells of a developing or regenerating urodele amphibian limb become endowed with these codings according to the position they occupy in the growing structure. At each limb level the cells are thought to possess the same PD positional information, whereas there are considerable variations along the transverse axes (Bryant and Gardiner, this volume).
KeywordsLimb Regeneration Digit Versus Vertebrate Limb Digit Regeneration Positional Codings
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