Intercalary Regeneration and Supernumerary Limbs after Proximal or Distal Transposition of the Developing Limb Bud of the Anuran Bufo Bufo in Contralateral Transplantations
Part of the
NATO ASI Series
book series (NSSA, volume 172)
It is known that developing limbs in Urodeles have the ability for intercalary regeneration. When blastemata of distal origin are grafted proximally without rotation of the transverse axes they interact with the stump so that the deleted skeletal patterns are replaced (Iten and Bryant, 1975; Stocum, 1975). However, when mature hands are grafted to a more proximal level, intercalary regeneration between mature tissues is very poor (Bryant and Iten, 1977, Michael and Hassona, 1982). A similar result is observed in Anurans (Maden, 1981, Michael and Hassona, 1982). Another feature of urodele limb transplantation is the production of supernumerary limbs when distal and proximal tissues are confronted (Iten and Bryant, 1975; Stocum, 1975; Stocum and Melton, 1977; Tank, 1978).
KeywordsSkeletal Element Bufo Bufo Larval Salamander Ambystoma Mexicanum Intercalary Regeneration
Bryant, S.V. and Iten, L.E., 1977, Intercalary and supernumerary regeneration and mature limbs of Notophthalmus viridescens
, J. Exp. Zool.
, 202:1–16.PubMedCrossRefGoogle Scholar
Iten and Bryant, 1975, The interaction between the blastema and stump in the establishment of the anterior-posterior and proximal-distal organization of the limb regenerate, Dev. Biol
.. 44:119–147.PubMedCrossRefGoogle Scholar
Maden, M., 1981, Experiments on Anuran limb buds and theirsignificance for principles of vertebrate limb development. J. Embryol. exp. Morph.
, 63:243–265.PubMedGoogle Scholar
Michael, I.M., and Hassona, A.A., 1982, Intercalary and supernumerary regeneration in limbs of stages of the Egyptian Toad, Bufo reqularis
, Reuss, J. Exp. Zool.
, 220:207–218.CrossRefGoogle Scholar
Rossi, A., 1959, Tavole cronologiche dello svillupo embryonale e larvale del Bufo bufo
(L). Monitore zool. ital.
, 66:2–3.Google Scholar
Stocum, D.L., 1975, Regulation after proximal or distal transposition of limb regeneration blastemas and determination of the proximal boundary of the regenerate. Dev. Biol.
, 45:112–136.PubMedCrossRefGoogle Scholar
Stocum, D.L., and D.S. Melton, 1977, Self organizationalcapacity of distally transplanted limb regeneration blastemas in larval salamanders. J. Exp. Zool.
, 201:451–462.PubMedCrossRefGoogle Scholar
Tank, P.W., 1978, The occurrence of supernumerary limbs following blastemal transplantation in the regenerating forelimbs of the axolotl, Ambystoma mexicanum
, Dev. Biol.
, 62:143–161.CrossRefGoogle Scholar
© Plenum Press, New York 1989