Mechanisms of Transdifferentiation of Pigment Epithelial Cells into Neural Retina: A Hypothesis

  • Victor Mitashov
Part of the NATO ASI Series book series (NSSA, volume 172)


The adult amphibian eye is a very convenient model for studying the events involved in the process that has been called transdifferentiation. In this system, which involves regeneration of the lens and/or retina in the adult newt or certain other amphibia, fully differentiated cells of adult somatic tissue are released from the control of the differentiated state and are channeled into a new pathway of cell type differentiation.


Pigment Epithelium Xenopus Laevis Retinal Pigment Epithelial Cell Growth Area Neural Retina 


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  1. Stroeva, O.G., and Mitashov, V.I., 1983, Retinal pigment epithelium: Proliferation and differentiation during development and regeneration, Int. Rev. Cytol., 83:221–293.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Victor Mitashov
    • 1
  1. 1.Institute of Developmental BiologyAcademy of Sciences of the USSRMoscowUSSR

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