The Role of Nerves in Accessory Limb Development
Accessory limbs are a type of ectopic supernumerary growth that may develop after trauma in urodeles. In the experiments described here, the removal of a patch of skin plus the reflection of a large nerve constituted the trauma that induced high proportion of growths in young axolotls. The regenerating axons of the reflected nerve supplied the necessary neurotrophic factor, and the Schwann cells of the same nerve may supply the mitotic cells for blastema formation.
KeywordsSchwann Cell Wound Epithelium Blastemal Cell Large Nerve Blastema Formation
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- Both, N.J. de, 1971, The regeneration territories — a critical note, Folia Morph., 19:177–181.Google Scholar
- Bunge, R.P., 1983, Recent observations on the control of Schwann cell functions, Anat. Rec., (Suppl. 1):3–26.Google Scholar
- Egar, M.W., 1988b, Does the nerve have dual roles in the production of accessory limbs? in: “Regeneration and Development”, The Proceedings of the 6th International Marcus Singer Symposium, S. Inoue et al., eds., Okada. Printing Company, Maebashi.Google Scholar
- Maden, M., 1981, Morphallaxis in an epimorphic system: size, growth control, and pattern formation during amphibian limb regeneration, J. Embryol. exp. Morph., 65:151–167.Google Scholar
- Maden, M., and Holder, N., 1984, Axial characteristics of nerve induced supernumerary limbs in the axolotl, Roux’s Arch. Dev. Biol., 193:394–401.Google Scholar
- Trampusch, H.A.L., and Harrebomee, A.E., 1969, Dedifferentia-tion and the interconvertibility of the different cell-types in the amphibian extremity, Acta Emb. Exp., 1969:35–69.Google Scholar
- Wallace, H., 1981, “Vertebrate Limb Regeneration”, John Wiley, New York.Google Scholar