Mechanisms Controlling Directed Axon Regeneration in the Peripheral and Central Nervous Systems of Amphibians

  • Nigel Holder
  • J. D. W. Clarke
  • Steve Wilson
  • Kim Hunter
  • D. A. Tonge
Part of the NATO ASI Series book series (NSSA, volume 172)


We describe a series of experiments designed to elucidate mechanisms which guide axons to their appropriate targets in the central and peripheral nervous systems of amphibia. In both systems it is evident that pathway guidance cues exist in the environment through which axons grow. In an initial attempt to examine guidance cues in the CNS at the cellular and molecular level we are focusing upon the role of radial glia and are examining neurite outgrowth within organ cultures and from explanted axolotl spinal cords.


Spinal Cord Axon Regeneration Dorsal Column Radial Glia Spinal Cord Transection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Nigel Holder
    • 1
  • J. D. W. Clarke
    • 1
  • Steve Wilson
    • 1
  • Kim Hunter
    • 1
  • D. A. Tonge
    • 2
  1. 1.Subject Groups, Division of Biomedical SciencesKing’s CollegeLondonUK
  2. 2.Anatomy and Human Biology and PhysiologyKing’s CollegeLondonUK

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