Mechanisms Controlling Directed Axon Regeneration in the Peripheral and Central Nervous Systems of Amphibians
We describe a series of experiments designed to elucidate mechanisms which guide axons to their appropriate targets in the central and peripheral nervous systems of amphibia. In both systems it is evident that pathway guidance cues exist in the environment through which axons grow. In an initial attempt to examine guidance cues in the CNS at the cellular and molecular level we are focusing upon the role of radial glia and are examining neurite outgrowth within organ cultures and from explanted axolotl spinal cords.
KeywordsSpinal Cord Axon Regeneration Dorsal Column Radial Glia Spinal Cord Transection
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