The Effects of Endocrine, Synaptic and Nutritional Inputs on Catecholamine-Containing Neurons

  • Richard J. Wurtman


The catecholamine norepinephrine is probably utilized as a neurotransmitter by a small but important fraction of the neurons in the brain (Wurtman, 1966). The cell bodies of most of these neurons are localized within the brain stem; their terminals are present in high concentrations within the structures of the limbic system and the septo-hypothalamo-mesencephalic continuum (Dahlström & Fuxe, 1965). The medial forebrain bundles may contain ascending and descending multisynaptic noradrenergic systems in addition to the “classical” monosynaptic pathways identified by his to-chemical fluorescence techniques.


Olfactory Bulb Norepinephrine Level Noradrenergic Neuron Medial Forebrain Bundle Brain Catecholamine 
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  1. ANTON-TAY, F., & WURTMAN, R. J. Norepinephrine: Turnover in rat brains after gonadectomy. Science, 1968, 159, 1245.PubMedCrossRefGoogle Scholar
  2. ANTON-TAY, F., PELHAM, R. W., & WURTMAN, R. J. Increased turnover of 3H-norepinephrine in rat brain following castration or treatment with ovine follicle-stimulating hormone. Endocrinology, 1969, 84, 1489–1492.PubMedCrossRefGoogle Scholar
  3. DAHLSTRÖM, A., & FUXE, K. Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbo-spinal neuron systems and IV. Distribution of monoamine nerve terminals in the central nervous system. Acta Physiologica Scandinavica, 1965, 64, Supplement 247, 1–87.CrossRefGoogle Scholar
  4. GLOWINSKI, J., & BALDESSARINI, R. J. Metabolism of norepinephrine in the central nervous system. Pharmacological Reviews, 1966, 18, 1201–1238.PubMedGoogle Scholar
  5. HELLER, A., SEIDEN, L. S., & MOORE, R. Y. Regional effects of lateral hypothalamic lesions on brain norepinephrine in the cat. International Journal of neuropharmacology, 1966, 5, 91–101.PubMedCrossRefGoogle Scholar
  6. POHORECKY, L. A., ZIGMOND, M. J., KARTEN, H., & WURTMAN, R. J. Enzymatic conversion of norepinephrine to epinephrine by the brain. Journal of Pharmacology and Experimental Therapeutics, 1969, 165, 190–195.PubMedGoogle Scholar
  7. SCRIMSHAW, N. S., & GORDON, J. E., (Eds.). Malnutrition, Learning and Behavior. Cambridge: M.I.T., 1968.Google Scholar
  8. SHOEMAKER, W. J., & WURTMAN, R. J. Effect of perinatal undernutrition on development of brain catecholamines in the rat. Federation Proceedings, 1970, 29, 496.Google Scholar
  9. WURTMAN, R. J. Catecholamines. Boston: Little, Brown & Co., 1966.Google Scholar
  10. WURTMAN, R. J. Brain catecholamines and the control of secretion from the anterior pituitary gland. In J. Meites (Ed.), Hypophysiotropic Hormones of the Hypothalamus: Assay and Chemistry. Baltimore: Williams & Wilkins, 1970.Google Scholar
  11. WURTMAN, R. J., ANTON-TAY, F., & ANTON, S. On the use of synthesis inhibitors to estimate Brain norepinephrine synthesis in gonadectomized rats. Life Sciences, 1969, 8 1015–1022.PubMedCrossRefGoogle Scholar
  12. ZIGMOND, M. J., & WURTMAN, R. J. Daily rhythm in the accumulation of brain catecholamines synthesized from circulating H-tyrosine. Journal of Pharmacology and Experimental Therapeutics, 1970, 172, 416–422.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Richard J. Wurtman
    • 1
  1. 1.Massachusetts Institute of TechnologyCambridgeUSA

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