Regional Brain RNA Metabolism as a Function of Different Experiences

  • Robert E. Bowman
  • Paul D. Kottler


In the last decade, studies of brain metabolism during simple behavioral experiences of short duration have provided evidence of measurable phenomena, particularly as regards changes in RNA metabolism. This area of investigation bears a logical resemblance to the study of electrical responses of brain during behavior, and can therefore be christened as chemoencephalography. The animal is subjected to a behavioral experience, sacrificed and the metabolic pattern of the brain at that point in time is analyzed. The intent is to discover metabolic events which may be specific to the experience and localized regionally in brain. These metabolic events may not necessarily be correlated in any simple way with the electrophysiology also occurring at the same time and may thus reflect neural processes different from those detectable by electrical signals.


Memory Consolidation Reversal Learning Magazine Training Reversal Training Intracranial Injection 
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  1. ALTMAN, J., & CHOROVER, S. L. Autoradiographic investigation of the distribution and utilization of intraventricularly injected adenine-3H, Uracil-3H and thymidine- H in brains of cats. Journal of Physiology, 1963, 169, 770–779.PubMedGoogle Scholar
  2. APPEL, S. H., DAVIS, W., & SCOTT, S. Brain polysomes: Response to environmental stimulation Science, 1967, 157, 836–838.PubMedCrossRefGoogle Scholar
  3. BENNETT, T. L. Hippocampal EEG correlates of behavior. Electroencephalography and clinical neurophysiology, 1970, 18, 17–23.CrossRefGoogle Scholar
  4. BOLLUM, F. J. Filter paper disk techniques for assaying radioactive molecules. In G. L. Cantoni & D. R. Davies (Eds.), Procedures in Nucleic Acid Research, New York: Harper & Row, 1966.Google Scholar
  5. BOOTH, D. A. Vertebrate brain ribonucleic acids and memory retention. Psychological Bulletin, 1967, 68, 149–177.PubMedCrossRefGoogle Scholar
  6. BOWMAN, R. E., & Deluna, R. F. Protein-binding assays for adrenocorticoids. Behavioral Research Methods and Instrumention, 1969, 1, 135–138.CrossRefGoogle Scholar
  7. BOWMAN, R. E., & Strobel, D. A. Brain RNA metabolism in the rat during learning. Journal of Comparative, and Physiological Psychology, 1969, 67, 448–456.CrossRefGoogle Scholar
  8. BRYAN, R. N., BLISS, E. L., & BECK, E. C. Incorporation of uridine-3H into mouse brain RNA during stress. Federation Proceedings, 1967, 26, 709.Google Scholar
  9. GLASSMAN, E. The biochemistry of learning: An elevation of the role of RNA and protein. Annual Review of Biochemistry, 1969, 38, 605–645.PubMedCrossRefGoogle Scholar
  10. HYDEN, H., & EGYHAZI, E. Nuclear RNA changes of nerve cells during a learning experiment in rats. Proceedings of the National Academy of Sciences, 1962, 48, 1366–1373.CrossRefGoogle Scholar
  11. HYDEN, H., & EGYHAZI, E. Glial RNA changes during a learning experiment in rats. Proceedings of the National Academy of Sciences, 1963, 49, 618–624.CrossRefGoogle Scholar
  12. HYDEN, H., & EGYHAZI, E. Changes in RNA content and base composition in cortical neurons of rats in a learning experiment involving transfer of handedness. Proceedings of the National Academy of Sciences, 1964, 52, 1030–1035.CrossRefGoogle Scholar
  13. JOHN, E. R. Mechanisms of Memory. New York: Academic Press, 1967.Google Scholar
  14. KANDEL, E. R., & SPENCER, W. A. Cellular neurophysiological approaches in the study of learning. Physiological Reviews, 1968, 48, 65–134.PubMedGoogle Scholar
  15. KARMOS, G., GRASTYAN, E., LOSONCZY, H., VERECZKEY, L., & GROSZ, J. The possible role of the hippocampus in the organization of the orientation reaction. Acta Physiologlca Academlae Scientiarum Hungaricae, 1965, 26, 131–141.Google Scholar
  16. KOTTLER, P. D., & BOWMAN, R. E. A simple intracranial needle guide for presenting backflow of injectant. Journal of the Experimental Analysis of Behavior, 1968, 11, 536.PubMedCrossRefGoogle Scholar
  17. RADULOVACKI, M., & ADEY, W. R. The hippocampus and the orienting reflex. Experimental Neurology, 1965, 12, 68–83.PubMedCrossRefGoogle Scholar
  18. SHASHOUA, V. E. RNA changes in goldfish brain during learning. Mature, 1968, 217, 111–113.Google Scholar
  19. SHASHOUA, V. E. RNA metabolism in goldfish brain during acquisition of new behavioral patterns. Proceedings of the National Academy of Sciences, 1970, 65, 161–167.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Robert E. Bowman
    • 1
  • Paul D. Kottler
    • 1
  1. 1.Wisconsin Regional Primate Research CenterUniversity of Wisconsin Psychology DepartmentMadisonUSA

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