Closing Remarks: Concerning Aspects of Specificity, Biological Function and Aging

  • Finn Wold
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)


Rather than attempt to undertake the virtually impossible task of making a proper scientific summary of the exciting proceedings of this 1st International Ischia Symposium in about 20 minutes, I have decided to briefly discuss three general topics or questions which may be common to all the posttranslational reactions discussed at this meeting.


Diphtheria Toxin Specificity Determinant Toxin Killing Aspartic Acid Racemization Biotin Binding Site 
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  1. 1.
    D.K. Struck and W.J. Lennarz. The function of saccharide lipids in synthesis of glycoproteins, In: “The Biochemistry of Glycoproteins”, W.J. Lennarz, ed., Plenun Press, New York (1980).Google Scholar
  2. 2.
    J. Augen and F. Wold. How much sequence information is needed for the regulation of ammo-terminal acetylation of eukaryotic proteins? Trends in Biochem. Sci. 11:494 (1986).CrossRefGoogle Scholar
  3. 3.
    M.-C. Shao and F. Wold. The use of avidin-biotinylglycan as the model for in vitro glycoprotein processing. J. Biol. Chem. 262:2968 (1987).PubMedGoogle Scholar
  4. 4.
    F. Sherman, J.W. Stewart and S. Tsunasawa. Methionine or not methionine at the beginning of proteins. BioEssays 3:27 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    C.C.Q. Chin and F. Wold. Studies on N-acylated proteins: the N-terminal sequences of two muscle enolases. Bioscience Reports 5:847 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    B.G. Van Ness, J.B. Howard and J.W. Bodley. ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyldiphthamide and its hydrolysis products. J. Biol. Chem. 255:10710 (1980).PubMedGoogle Scholar
  7. 7.
    J.-Y. C. Chen, J.W. Bodley and D.M. Livingston. Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae Mol. Cell Biol. 5:3357 (1985).PubMedGoogle Scholar
  8. 8.
    A.B. Robinson, J.W. Scotchler and J.H. McKerrow. Rates of enzymatic deamidation of glytaminyl and asparaginyl residues in pentapeptides. J. Am. Chem. Soc. 95:8156 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    P.M. Masters, J.L. Bada and J.S. Zigler, Jr. Aspartic acid racemization in the human lens during aging and in cataract formation. Nature 268:71 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    N.G. Watkins, C.I. Neglia-Fisher, D.G. Dyer, S.R. Thorpe and J.W. Baynes. Effect of phosphate on the kinetics and specificity of glycation of proteins. J. Biol. Chem. 262:7207 (1987).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Finn Wold
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Texas Medical SchoolHoustonUSA

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