Post-Translational Modifications of the Elongation Factor 2

  • C. Balestrieri
  • A. Giovane
  • L. Quagliuolo
  • L. Servillo
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)


The elongation cycle in the course of protein biosynthesis is terminated by the translocation, which consists of a ribosome shift in the 5‵-3‵ direction along the mRNA, together with the transfer of the peptidyl-tRNA from the A to the P site and the release of the deacylated tRNA. The translocation is accompanied by the hydrolysis of a GTP molecule and is catalyzed, in the eukaryotic cells by a monomeric protein, the elongation factor 2 (EF-2), the molecular weight of which ranges between 90,000 and 110,000 in the sources so far examined (Bermek, 1978).


Elongation Factor Protein Biosynthesis Diphtheria Toxin FEBS Letter Beef Liver 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • C. Balestrieri
    • 1
  • A. Giovane
    • 1
  • L. Quagliuolo
    • 1
  • L. Servillo
    • 1
  1. 1.Institute of Chemistry and Biological Chemistry, 1st Medical SchoolUniversity of NaplesNaplesItaly

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