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Advances in Post-Translational Modifications of Proteins and Aging pp 549–557Cite as

Homology between the Catalytic Subunits of Protein Phosphatases 1 and 2A Deduced from the cDNA

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Part of the book series: Advances in Experimental Medicine and Biology ((NATO ASI F,volume 231))

Abstract

A wide variety of extracellular signals transmit information to the cell interior by activating transmembrane signalling systems that control the production of a relatively small number of chemical mediators or “second messengers”. These substances (cyclic AMP, cyclic GMP, diacylglycerol and calcium ions) each activate particular protein kinases allowing them to phosphorylate key regulatory proteins and so translate external signals into cellular responses1,2. However, the steady state level of phosphorylation of any protein depends on the activities of protein phosphatases, as well as protein kinases, raising two important questions. How many protein phosphatases are present in cells, and are they also controlled by “second messengers”?

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Authors and Affiliations

  1. Department of Biochemistry, University of Dundee, Dundee, DD1 4HN, Scotland

    Patricia T. W. Cohen, Norbert Berndt, Odete da Cruz e Silva & David G. Campbell

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  1. Patricia T. W. Cohen
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  2. Norbert Berndt
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  3. Odete da Cruz e Silva
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  4. David G. Campbell
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Editor information

Editors and Affiliations

  1. University of Naples, Naples, Italy

    Vincenzo Zappia , Patrizia Galletti  & Raffaele Porta ,  & 

  2. University of Texas Health Science Center, Houston, Texas, USA

    Finn Wold

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© 1988 Springer Science+Business Media New York

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Cohen, P.T.W., Berndt, N., da Cruz e Silva, O., Campbell, D.G. (1988). Homology between the Catalytic Subunits of Protein Phosphatases 1 and 2A Deduced from the cDNA. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_46

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  • DOI: https://doi.org/10.1007/978-1-4684-9042-8_46

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9044-2

  • Online ISBN: 978-1-4684-9042-8

  • eBook Packages: Springer Book Archive

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