Mechanisms of Transformation by Protein-Tyrosine Kinases

  • John C. Bell
  • Louis Mahadevan
  • William H. Colledge
  • Michael J. Fry
  • A. Raymond Frackelton
  • Michael G. Sargent
  • J. Gordon Foulkes
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)


In multicellular organisms there must be stringent control over the processes of cellular proliferation and differentiation. Thus sophisticated networks of regulatory molecules have evolved to sense and transmit signals within and between normal cells. From the study of growth factor receptors and the polypeptide products of particular oncogenes, it appears that protein tyrosine kinases, their substrates and phosphatase counterparts are essential components of some of these regulatory pathways.


Epidermal Growth Factor Receptor Protein Tyrosine Kinase Rous Sarcoma Virus Epidermal Growth Factor Stimulation Protein Tyrosine Kinase Activity 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • John C. Bell
    • 1
  • Louis Mahadevan
    • 2
  • William H. Colledge
    • 2
  • Michael J. Fry
    • 2
  • A. Raymond Frackelton
    • 3
  • Michael G. Sargent
    • 2
  • J. Gordon Foulkes
    • 2
  1. 1.Department of BiochemistryMcGill UniversityMontrealCanada
  2. 2.Laboratory of Eukaryotic Molecular Genetics and Laboratory of EmbryogenesisNIMRMill Hill, LondonUK
  3. 3.Department of MedicineBrown UniversityProvidenceUSA

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