Skip to main content

p34, A Protein Kinase Involved in Cell Cycle Regulation in Eukaryotic Cells

  • Chapter
Advances in Post-Translational Modifications of Proteins and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((NATO ASI F,volume 231))

  • 260 Accesses

Abstract

Investigation of the biochemical basis of cellular transformation is a major area of current research directed towards understanding the problem of tumorigenesis and human cancer. Much progress has been made in identifying primary oncogenic agents, both chemical and viral, in addition to the discovery of cellular oncogenes (Bishop, 1985). Biochemical activities have been associated with the products of some viral and cellular oncogenes, most notably those which belong to the protein kinase family (Erikson and Erikson, 1980).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Beach, D. and Nurse, P. 1981, High-frequency transformation of the fission yeastSchizosaccharomyces pombe, Nature, 290:140–142.

    Article  PubMed  CAS  Google Scholar 

  • Beach, D., Durkacz, B. and Nurse, P. 1982, Functionally homologous cell cycle control genes in budding and fission yeast. Nature, 300:706–709.

    Article  PubMed  CAS  Google Scholar 

  • Bishop, J. M. 1985, Viral oncogenes, Cell 42:23–38.

    Article  PubMed  CAS  Google Scholar 

  • Booher, R. and Beach D. 1986,. Site-specific mutagenesis of cdc2 +, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe, Molec. Cell. Biol. 6: 3523–3530.

    PubMed  CAS  Google Scholar 

  • Costello, G., Rodgers, L. and Beach, D. 1986, Fission yeast enters the stationary phase GO state from either mitotic Gl or G2, Current Genetics 11: 119–125.

    Article  Google Scholar 

  • Draetta, G., Brizuela, L., Potashkin, J. and Beach, D. 1987, Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2 + and sucl +, Cell, in press.

    Google Scholar 

  • Ellis, R.W„ DeFeo, D., Shin, T.Y., Gonda, M.A, Young, HA., Tsuchida, N., Lowy, D.R and Scolnick, EM. 1981, The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes, Nature 292: 506–511.

    Article  PubMed  CAS  Google Scholar 

  • Erikson, E. and Erikson, R.L. 1980, Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product. Cell 21:829–836.

    Article  PubMed  CAS  Google Scholar 

  • Fukui, Y. and Kaziro, Y. 1985, Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe, EMBO J. 4: 687–691.

    PubMed  CAS  Google Scholar 

  • Hartwell, L.H. 1974, Saccharomyces cerevisiae cell cycle, Bact. Rev. 38: 164–198.

    PubMed  CAS  Google Scholar 

  • Hindley, J. and Phear, G A. 1984, Sequence of the cell division gene cdc2* from Schizosaccharomyces Pombe: patterns of splicing and homology to protein kinases, Gene 31: 129–134.

    Article  PubMed  CAS  Google Scholar 

  • Hindley, J., Phear, G., Stein, M. and Beach, D. 1987, Sucl + encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces Pombe, Molec. Cell. Biol. 7: 504–511.

    PubMed  CAS  Google Scholar 

  • Lorincz, A.T. and Reed, SX 1984, Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes, Nature 307:183–185.

    Article  PubMed  CAS  Google Scholar 

  • Mao, J., Schaack, J., Sharp, S., Yamada, H., Kohli, J. and Soll, D. In Molecular genetics of yeast (D. Von Wettstein, ed.) 276–289 (1980).

    Google Scholar 

  • Mitchison, J.M. 1970, Physiological and Cytological Methods for S. pombe. In Methods in Cell Physiology Ed. Prescott, Vol. 4.

    Google Scholar 

  • Nurse, P. and Fantes, P. 1981, Cell Cycle controls in fission yeast: a genetic analysis, in P.C.L John Ed. The Cell Cycle, Cambridge 85–98.

    Google Scholar 

  • Nurse, P. and Thuriaux, P. 1980, Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe, Genetics 96: 627–637.

    PubMed  CAS  Google Scholar 

  • Nurse, P. and Bissett, Y. 1981, gene required in Gl for committment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292: 558–560.

    Article  PubMed  CAS  Google Scholar 

  • Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J. and Wigler, M. 1984, Genes in Saccharomyces cerevisiae encode proteins with domains homologous to the mammalian ras proteins, Cell 36: 607–612.

    Article  PubMed  CAS  Google Scholar 

  • Pringle, J.R. and Hartwell, L.H. 1981, The Saccharomyces cerevisîae cell cycle, in the Molecular Biology of the Yeast. (Strathern et al. eds.) Cold Spring Harbor, NY.

    Google Scholar 

  • Reed, S.J., Hadwiger, JA. and Lorincz, A.T. 1985, Protein kinase activity associated with the product of the yeast cell cycle gene CDC28, Proc. Natl. Acad. Sci. 82: 4055–4059.

    Article  PubMed  CAS  Google Scholar 

  • Schechter, Y., Patchornik, A. and Burstein, Y. 1976, Selective chemical cleavage of tryptophenyl peptide bonds by oxidative chlorination with N-chlorosuccinimide, Biochemistry 15: 5071–5075.

    Article  Google Scholar 

  • Simanis, V. and Nurse, P. 1986, The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation, Cell 45: 261–268.

    Article  PubMed  CAS  Google Scholar 

  • Studier, F.W. and Moffat, BA. 1986, Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes, J. Mol. Biol. 189: 113–130.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer Science+Business Media New York

About this chapter

Cite this chapter

Draetta, G., Brizuela, L., Beach, D. (1988). p34, A Protein Kinase Involved in Cell Cycle Regulation in Eukaryotic Cells. In: Zappia, V., Galletti, P., Porta, R., Wold, F. (eds) Advances in Post-Translational Modifications of Proteins and Aging. Advances in Experimental Medicine and Biology, vol 231. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9042-8_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-9042-8_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-9044-2

  • Online ISBN: 978-1-4684-9042-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics