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Control of S6 Phosphorylation during the Mitogenic Response

  • Lisa M. Ballou
  • Paul Jenö
  • George Thomas
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)

Abstract

S6 is an Mr = 31,000 protein integral to the small 40S subunit of eukaryotic ribosomes. During such processes as transformation, tissue regeneration, cell growth and development S6 becomes extensively phosphorylated. A central problem in the field of growth control has been to determine what effect this has on the regulation of protein synthesis. In this article we discuss some of the evidence that links S6 phosphorylation to increased rates of translation and then present some of our own work concerning the control of S6 phosphorylation during the mitogenic response.

Keywords

Ribosomal Protein Mitogenic Response Kinase Inactivator Phosphorylase Phosphatase Tyrosyl Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Lisa M. Ballou
    • 1
  • Paul Jenö
    • 1
  • George Thomas
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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