Control of S6 Phosphorylation during the Mitogenic Response
S6 is an Mr = 31,000 protein integral to the small 40S subunit of eukaryotic ribosomes. During such processes as transformation, tissue regeneration, cell growth and development S6 becomes extensively phosphorylated. A central problem in the field of growth control has been to determine what effect this has on the regulation of protein synthesis. In this article we discuss some of the evidence that links S6 phosphorylation to increased rates of translation and then present some of our own work concerning the control of S6 phosphorylation during the mitogenic response.
KeywordsRibosomal Protein Mitogenic Response Kinase Inactivator Phosphorylase Phosphatase Tyrosyl Protein
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