Structural Basis for the Specificity of Protein Phosphorylation and Dephosphorylation Processes
The phosphorylation of seryl, threonyl and tyrosyl residues is in most instances a reversible process, affecting only a minority of the whole cellular proteins and resulting from the coordinated activity of protein kinases and protein phosphatases (reviewed in 1) . Both these classes of enzymes therefore must be endowed with more or less pronounced time and substrate selectivity. Timeliness is mainly ensured by extra- and intracellular stimuli, either directly or through the generation of second messengers, like cyclic nucleotides, Ca2+, diacylglycerols etc, and by physiological inhibitors, that can modulate the activity of the phosphorylating and dephosphorylating enzymes.
KeywordsProtein Kinase Protein Phosphatase Casein Kinase Peptide Substrate Dependent Protein Kinase
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