Histone Methylation and Modulation of Gene Expression in Response to Heat Shock and Chemical Stress in Drosophila
All prokaryotic and eukaryotic organisms examined respond to an exposure to supraoptimal temperatures or to various forms of cellular stress by the rapid induction of a small set of proteins, the heat shock proteins 1–3. In Drosophila where this response was originally observed, extensive gene regulation has been shown to operate at the transcriptional and post-transchptional levels4. In this system, the rapid activation of the heat shock genes observed at the puff level is accompanied by an equally rapid repression of the transcription of most of the genes active prior to the shock (referred to hereafter as the normal genes). The molecular mechanisms involved in the rapid induction or repression of specific genes in response to stress are still unclear.
KeywordsHeat Shock Methylation Pattern Histone Methylation Core Histone Heat Shock Gene
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- 1.B.G. Atkinson and D.B. Waiden (Eds), “Changes In Eukaryotic Gene Expression in Response to Environmental Stress”, Academic Press, Orlando (1985).Google Scholar
- 2.L. Nover (Ed.), “Heat Shock Response of Eukaryotic Cells”, VEB Georg Thieme, Leipzig (1984).Google Scholar
- 9.R. Desrosiers and R.M. Tanguay, Further characterization of the posttranslational modifications of core histones in response to heat and arsenite stress in Drosophila, Biochem. Cell Biol .64: 750 (1986).Google Scholar
- 10.W.K. Paik and S. Kim, “Protein Methylation” John Wiley & Sons, New-York (1980).Google Scholar
- 16.P. Byvoet and C.S. Baxter, Histone methylation, a functional enigma, in “Chromosomal Proteins and their Role in the Regulation of Gene Expression”, G.S. Stein and L.V. Kleinsmith, eds., Academic Press, New-York(1975).Google Scholar