Mammalian Protein Methylesterase

  • Kannappan Veeraragavan
  • Claude Gagnon
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)


Posttranslational modification is an important event in protein structure and function. One of these modifications involves the transfer of methyl group from S-adenosyl-L-methionine to the free carboxyl groups of aspartyl and glutamyl side chains in proteins (Fig. 1). The enzyme involved in this reaction is protein-carboxyl methylase (PC.M; S-adenosylmethionine, protein-carboxyl 0-methyltransferase, EC This ubiquitous enzyme esterifies free carboxyl groups of proteins resulting in the neutralization of their negative charges (Liss et al., 1969; Kim and Paik, 1970; Kim and Paik, 1971; Morin and Liss, 1973).


Luteinizing Hormone Kidney Homogenate Methanol Formation Methyl Accept Chemotaxis Protein Carboxyl Methyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used


protein-carboxyl methylase


protein methylesterase




sodium dodecyl sulfate


parachloromercuribenzoic acid


phenylmethyl sulfonylf1uoride




N-[N-(L-3-trans-carboxyoxi ran-2-carbonyl)-L-leucyl]-agmatine


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Kannappan Veeraragavan
    • 1
  • Claude Gagnon
    • 1
  1. 1.Urology Research Laboratory, Royal Victoria Hospital and Faculty of MedicineMcGill UniversityMontrealCanada

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