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Substrates of Protein Carboxyl Methyltransferase: Kinetics and Mechanism of their Formation

  • Piet J. M. van den Oetelaar
  • Herman J. Hoenders
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)

Abstract

Protein carboxyl methyltransferase (PCM, EC 2.1.1.77) is an ubiquitous enzyme capable of methylating a great variety of proteins. The reaction that it catalyzes takes place in a sub-stoichiometric way. This puzzling fact was explained when Clarke and Aswad and their co-workers reported that PCM only recognizes D-aspartic and L-isoaspartic residues (for review see reference 1).

Keywords

Human Lens Native Protein Structure Cyclic Imide Adjacent Amino Acid Aspartic Acid Racemization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Piet J. M. van den Oetelaar
    • 1
  • Herman J. Hoenders
    • 1
  1. 1.Department of BiochemistryUniversity of NijmegenNijmegenThe Netherlands

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