Substrates of Protein Carboxyl Methyltransferase: Kinetics and Mechanism of their Formation
Protein carboxyl methyltransferase (PCM, EC 220.127.116.11) is an ubiquitous enzyme capable of methylating a great variety of proteins. The reaction that it catalyzes takes place in a sub-stoichiometric way. This puzzling fact was explained when Clarke and Aswad and their co-workers reported that PCM only recognizes D-aspartic and L-isoaspartic residues (for review see reference 1).
KeywordsHuman Lens Native Protein Structure Cyclic Imide Adjacent Amino Acid Aspartic Acid Racemization
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