Macrophage Transglutaminases: Characterization of Molecular Species and Measurement of Enzymatic Modification by Cigarette Smoke Components

  • William J. Roth
  • Soo Il Chung
  • Linga Raju
  • Aaron Janoff
Part of the Advances in Experimental Medicine and Biology book series (NATO ASI F, volume 231)


Transglutaminases (E.C. are a family of calcium-dependent thiol enzymes which catalyze the covalent cross-linking of peptide-bound glutamine residues to a variety of primary amines, including the epsilonamino group of peptide-bound lysine residues (reviewed by Folk, 1980). This latter reaction represents a unique example of enzyme-catalyzed cross-linking, resulting in the formation of an epsilon-(gamma-glutamyl) lysine bond.


Cigarette Smoke Alveolar Macrophage Homologous Serum Smoke Exposure Factor Xiii 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • William J. Roth
    • 1
  • Soo Il Chung
    • 2
  • Linga Raju
    • 3
  • Aaron Janoff
    • 1
  1. 1.Department of PathologyS.U.N.Y. at Stony BrookStony BrookUSA
  2. 2.N.I.D.R.National Institutes of HealthBethesdaUSA
  3. 3.Pulmonary DivisionNassau County Medical CenterEast MeadowUSA

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