Macrophage Transglutaminases: Characterization of Molecular Species and Measurement of Enzymatic Modification by Cigarette Smoke Components
Transglutaminases (E.C. 22.214.171.124) are a family of calcium-dependent thiol enzymes which catalyze the covalent cross-linking of peptide-bound glutamine residues to a variety of primary amines, including the epsilonamino group of peptide-bound lysine residues (reviewed by Folk, 1980). This latter reaction represents a unique example of enzyme-catalyzed cross-linking, resulting in the formation of an epsilon-(gamma-glutamyl) lysine bond.
KeywordsCigarette Smoke Alveolar Macrophage Homologous Serum Smoke Exposure Factor Xiii
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