Proline and Hydroxyproline in Lymphedema

  • A. K. Cordeiro
  • F. F. Baracat


The fundamental component of collagen is the triple chain of tropocollagen which is changed into components of connective tissue:
  1. (1)


  2. (2)


  3. (3)

    insoluble fibers: reticular and collagen

  4. (4)


  5. (5)




Collagen Metabolism Insoluble Fiber Urinary Hydroxyproline Characteristic Amino Acid Iduronic Acid 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. Battezzati and I. Donini, Il sistema linfático nella pratica clinica, Piccin Editores, Padova, 1967.Google Scholar
  2. 2.
    R. Bourrilon and J. L. Vernay, Biochem. Biophys. Acta, 117:319, 1966.CrossRefGoogle Scholar
  3. 3.
    A. K. Cordeiro, F. F. Baracat, E. Bolanho, and A. J. Brandi, Linfedema: estudo do metabolismo do colageno (to be published).Google Scholar
  4. 4.
    De Bruz, cited by Battezzati (1), p. 180.Google Scholar
  5. 5.
    F. Duran-Reynold, La substance fondamentale du mesenchyme et les facteurs de diffusion dans Infection, Sem. Hôp. Paris, 28:1047, 1952.Google Scholar
  6. 6.
    M. Földi, Diseases of Lymphatics and Lymph Circulation, Akademiai Kiado, Budapest, 1969.Google Scholar
  7. 7.
    H. Hanson and B. Wiederanders, Clin. Chim. Acta, 25:255, 1969.PubMedCrossRefGoogle Scholar
  8. 8.
    M. R. Henry, Clinical Chemistry, Harper & Row, New York, 1964.Google Scholar
  9. 9.
    H. E. Jasin, W. Find, W. Wise, and M. Ziff, Relationship between urinary hydroxyproline and growth, J. Clin. Invest., 41:1928, 1962.PubMedCrossRefGoogle Scholar
  10. 10.
    H. Keiser, E. C. LeRoy, S. Udenfriend, and A. Sjoerdsma, Collagen-like protein in human plasma, Science, 142:1678, 1963.PubMedCrossRefGoogle Scholar
  11. 11.
    E. C. LeRoy and A. Sjoerdsma, Clinical significance of a hydroxyproline-containing protein in human plasma, J. Clin. Invest., 44:914, 1965.PubMedCrossRefGoogle Scholar
  12. 12.
    E. C. LeRoy, Adv. Clin. Chem., 10:213, 1967.CrossRefGoogle Scholar
  13. 13.
    E. C. LeRoy, A. Kaplan, S. Udenfriend, and A. Sjoerdsma, A hydroxyproline-containing collagen-like protein in plasma and a procedure for its assay, J. Biol. Chem., 239:3350, 1964.PubMedGoogle Scholar
  14. 14.
    S. Lindstedt and D. J. Prockop, J. Biol. Chem., 236:1399, 1961.PubMedGoogle Scholar
  15. 15.
    D. J. Prockop and K. I. Kivirikko, Ann. Intern. Med., 66:1243, 1967.Google Scholar
  16. 16.
    D. J. Prockop and S. Udenfriend, A specific method for the analysis of hydroxyproline in tissues and urine, Analyt. Biochem., 1:228, 1960.PubMedCrossRefGoogle Scholar
  17. 17.
    D. J. Prockop, H. R. Keiser, and A. Sjoerdsma, Gastrointestinal absorption and renal excretion of hydroxyproline peptides, Lancet, 2:257, 1962.Google Scholar
  18. 18.
    D. J. Prockop and A. Sjoerdsma, Significance of urinary hydroxyproline in man, J. Clin. Invest., 40:843, 1961.PubMedCrossRefGoogle Scholar
  19. 19.
    D. J. Prockop, Isotopic studies on collagen degradation and urinary excretion of hydroxyproline, J. Clin. Invest., 43:453, 1964.PubMedCrossRefGoogle Scholar
  20. 20.
    J. D. Smiley and M. Ziff, Urinary hydroxyproline excretion and growth, Physiol. Rev., 44:30, 1964.PubMedGoogle Scholar
  21. 21.
    H. Z. Stegeman, Z. Physiol. Chem., 31:41, 1958.CrossRefGoogle Scholar
  22. 22.
    W. Troll and R. K. Cannan, J. Biol. Chem., 200:803, 1953.PubMedGoogle Scholar
  23. 23.
    P. H. Weiss and L. Klein, J. Clin. Invest., 48:1, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. K. Cordeiro
    • 1
  • F. F. Baracat
    • 1
  1. 1.Instituto Arnaldo Vieira de CarvalhoSão PauloBrazil

Personalised recommendations