Proline and Hydroxyproline in Lymphedema

  • A. K. Cordeiro
  • F. F. Baracat


The fundamental component of collagen is the triple chain of tropocollagen which is changed into components of connective tissue:
  1. (1)


  2. (2)


  3. (3)

    insoluble fibers: reticular and collagen

  4. (4)


  5. (5)




Collagen Metabolism Insoluble Fiber Urinary Hydroxyproline Characteristic Amino Acid Iduronic Acid 
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  1. 1.
    M. Battezzati and I. Donini, Il sistema linfático nella pratica clinica, Piccin Editores, Padova, 1967.Google Scholar
  2. 2.
    R. Bourrilon and J. L. Vernay, Biochem. Biophys. Acta, 117:319, 1966.CrossRefGoogle Scholar
  3. 3.
    A. K. Cordeiro, F. F. Baracat, E. Bolanho, and A. J. Brandi, Linfedema: estudo do metabolismo do colageno (to be published).Google Scholar
  4. 4.
    De Bruz, cited by Battezzati (1), p. 180.Google Scholar
  5. 5.
    F. Duran-Reynold, La substance fondamentale du mesenchyme et les facteurs de diffusion dans Infection, Sem. Hôp. Paris, 28:1047, 1952.Google Scholar
  6. 6.
    M. Földi, Diseases of Lymphatics and Lymph Circulation, Akademiai Kiado, Budapest, 1969.Google Scholar
  7. 7.
    H. Hanson and B. Wiederanders, Clin. Chim. Acta, 25:255, 1969.PubMedCrossRefGoogle Scholar
  8. 8.
    M. R. Henry, Clinical Chemistry, Harper & Row, New York, 1964.Google Scholar
  9. 9.
    H. E. Jasin, W. Find, W. Wise, and M. Ziff, Relationship between urinary hydroxyproline and growth, J. Clin. Invest., 41:1928, 1962.PubMedCrossRefGoogle Scholar
  10. 10.
    H. Keiser, E. C. LeRoy, S. Udenfriend, and A. Sjoerdsma, Collagen-like protein in human plasma, Science, 142:1678, 1963.PubMedCrossRefGoogle Scholar
  11. 11.
    E. C. LeRoy and A. Sjoerdsma, Clinical significance of a hydroxyproline-containing protein in human plasma, J. Clin. Invest., 44:914, 1965.PubMedCrossRefGoogle Scholar
  12. 12.
    E. C. LeRoy, Adv. Clin. Chem., 10:213, 1967.CrossRefGoogle Scholar
  13. 13.
    E. C. LeRoy, A. Kaplan, S. Udenfriend, and A. Sjoerdsma, A hydroxyproline-containing collagen-like protein in plasma and a procedure for its assay, J. Biol. Chem., 239:3350, 1964.PubMedGoogle Scholar
  14. 14.
    S. Lindstedt and D. J. Prockop, J. Biol. Chem., 236:1399, 1961.PubMedGoogle Scholar
  15. 15.
    D. J. Prockop and K. I. Kivirikko, Ann. Intern. Med., 66:1243, 1967.Google Scholar
  16. 16.
    D. J. Prockop and S. Udenfriend, A specific method for the analysis of hydroxyproline in tissues and urine, Analyt. Biochem., 1:228, 1960.PubMedCrossRefGoogle Scholar
  17. 17.
    D. J. Prockop, H. R. Keiser, and A. Sjoerdsma, Gastrointestinal absorption and renal excretion of hydroxyproline peptides, Lancet, 2:257, 1962.Google Scholar
  18. 18.
    D. J. Prockop and A. Sjoerdsma, Significance of urinary hydroxyproline in man, J. Clin. Invest., 40:843, 1961.PubMedCrossRefGoogle Scholar
  19. 19.
    D. J. Prockop, Isotopic studies on collagen degradation and urinary excretion of hydroxyproline, J. Clin. Invest., 43:453, 1964.PubMedCrossRefGoogle Scholar
  20. 20.
    J. D. Smiley and M. Ziff, Urinary hydroxyproline excretion and growth, Physiol. Rev., 44:30, 1964.PubMedGoogle Scholar
  21. 21.
    H. Z. Stegeman, Z. Physiol. Chem., 31:41, 1958.CrossRefGoogle Scholar
  22. 22.
    W. Troll and R. K. Cannan, J. Biol. Chem., 200:803, 1953.PubMedGoogle Scholar
  23. 23.
    P. H. Weiss and L. Klein, J. Clin. Invest., 48:1, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • A. K. Cordeiro
    • 1
  • F. F. Baracat
    • 1
  1. 1.Instituto Arnaldo Vieira de CarvalhoSão PauloBrazil

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