Tissue and Capillary Force Changes During the Formation of Intra-Alveolar Edema

  • R. E. Drake
  • A. E. Taylor


The Starling forces, capillary pressure (Pc) plasma colloid osmotic pressure (Лc), tissue colloid osmotic pressure (Лt) and tissue fluid pressure (Pt) are related to the volume movement (JV) across any capillary system by the relationship:
$$J_v = K_{FC} \left[ {\left( {P_c - P_t } \right) - \sigma _c \left( {\pi _c - \pi _t } \right)} \right]$$
where KF, C is the filtration coefficient of the capillary bed (ml/min-mm Hg-100 gm) and σ is the Staverman reflection coefficient of the plasma proteins (σ of the protein is equal to 1 if the membrane is impermeable to the protein and is equal to 0 if the protein is as permeable as water in the membrane i.e. velocity of solute/velocity of water = 1). Obviously there is not just one σ but a σ for each of the various protein fractions in the body fluids (α1, α2. and β globulins, albumin and γ globulins); however, for practical purposes we can assume that σ =1 for all plasma proteins and calculate total ΔЛ by the use of the Landis and Pappenheimer equation (1,2).


Capillary Pressure Lymph Flow Colloid Osmotic Pressure Total Plasma Protein Plasma Protein Concentration 
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  1. 1.
    Staverman, A.J. The theory of measurement of osmotic pressure. Rec. Trav. Chim. 70:344–352, 1951.CrossRefGoogle Scholar
  2. 2.
    Landis, E.M., and J.R. Pappenheimer. Exchange of substance through capillary walls. In: Handbook of Physiology. Circulation. Washington, D.C.: Am. Physiol. Soc. 1963, sect. 2, vol. 2, chapt. 29, p. 961–1034.Google Scholar
  3. 3.
    Gaar, K.A., A.E. Taylor, L.J. Owens and A.C. Guyton. Effect of capillary pressure and plasma protein on development of pulmonary edema. Am. J. Physiol. 213:74–82, 1967.Google Scholar
  4. 4.
    Drake, R.E. and A.E. Taylor. Calculation of the edema safety factor in isolated dog lung. (abs.) Fed. Proc. 34:400, 1975.Google Scholar
  5. 5.
    Casley-Smith. A model of lymphatic concentrating ability. Microvascular Research. In Press.Google Scholar
  6. 6.
    Guyton, A.C., A.E. Taylor, R.E. Drake, H.I. Chen, and R.E. Brance. Physical and hemodynamic determinations of transcapillary exchange in the lungs. In: Krogh Symposium on Capillaries, Srinagar, Karhmir, India. Oct. 14, 1974.Google Scholar
  7. 7.
    Johnson, P.C. and D.R. Richardson. The influence of venous pressure on filtration forces in the intestine. Microvascular Research. 7:296–306, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Taylor, A.E. and H. Gibson. Concentrating ability of lymphatic vessels. Lymphology. In Press.Google Scholar
  9. 9.
    Staub, N.C. Pulmonary edema. Physiol. Rev. 54:678–811. 1974.PubMedCrossRefGoogle Scholar
  10. 10.
    Guyton, A.C., and A.W. Lindsey. Effect of elevated left arterial pressure and decreased plasma protein concentration on the development of pulmonary edema. Circulation Res. 7(4):649–657, 1959.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. E. Drake
    • 1
  • A. E. Taylor
    • 1
  1. 1.University of Mississippi Medical CenterJacksonUSA

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