Model of Fluid Transport in the Small Intestine: Effect of Venous Pressure Elevation on Fluid Transport

  • N. A. Mortillaro
  • Aubrey E. Taylor


The intestine transports large volumes of fluid daily, approximately 9 liters, and this transported volume must not only traverse the mucosal epithelial cells, but the fluid must flow through the interstitium and finally enter either the lymphatics or capillaries. Figure 1 is a schematic, idealized representation of the mucosal membrane, intestinal interstitium and capillary. There are two possible flows across the mucosa: 1) The volume flow associated with the active transport (JV, MA) and a passive volume flow (JV, MP) that is related to the Starling forces operating across the mucosal membrane:
$${\text{J}}_{{\text{V,M}}} {\text{ = J}}_{{\text{V,MA}}} {\text{ - J}}_{{\text{V,MP}}} {\text{;}}$$
$$= J_{V,MA} - \left[ {K_{F,M} \left( {P_T - P_M - O_M \left( {\pi _T - \pi _M } \right.} \right)} \right]$$
where JV,M is the net volume movement across the mucosal membrane, KF,M is the filtration coefficient of the mucosal membrane (ml/min/ mm Hg/100 gm), PT is the tissue fluid pressure, PM is the mucosal pressure, ЛT is the tissue colloid osmotic pressure, ЛM is the mucosal colloid osmotic pressure and σM is the reflection coefficient of the mucosal membrane (σ = 1 if the membrane is impermeable to the plasma proteins and is equal to 0 if the proteins are freely permeable).


Venous Pressure Fluid Transport Lymph Flow Colloid Osmotic Pressure Mucosal Membrane 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • N. A. Mortillaro
    • 1
  • Aubrey E. Taylor
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJacksonUSA

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