Lymph and Tissue Fluid Flow Deduced from Microvascular Exchange Parameters

  • M. Intaglietta


Lymph is presumed to originate as a consequence of the imbalance between the filtration and absorptive mode of exchange at the level of blood capillaries. The factors which regulate this phenomenon are embodied in the so called Starling Hypothesis of fluid exchange. According to the commonly accepted interpretation of this theory exchange of fluid takes place at the level of blood capillaries, in such a fashion that at the arterial beginning, fluid filters out of the microcirculation, and is subsequently reabsorbed at the venous end by the osmotic effect caused by the plasma protein. According to this theory, therefore, the microcirculation has the functional properties of an osmometer. These concepts have been directly validated at the level of the microscopic exchange vessels of the frog by Landis (1927), and in mammals by Zweifach and Intaglietta (1968).


Hydraulic Conductivity Blood Capillary Osmotic Effect Exchange Flux Colloid Osmotic Pressure 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • M. Intaglietta
    • 1
  1. 1.AMES-BioengineeringUniversity of California, San DiegoLa JollaUSA

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