Lymphatic Transport of Melanosomes from the Tissue to the Lymph Node. An Electron Microscopic Study

  • Moriya Ohkuma


Deposit of melanin-like particles in the lymph node of the healthy and diseased human as well as lipomelanic reticulosis of the lymph node associated with the various skin diseases have been reported by many investigators. This experiment was aimed to explain how the melanin reaches the lymph node from the connective tissue. However melanosomes were not put into the skin but into the abdominal cavity of the mice, because the former might injure the lymphatic capillary inducing its changed permeability (1).


Lymph Node Regional Lymph Node Abdominal Cavity Skin Disease Electron Microscopic Study 
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  1. 1.
    Ohkuma, M.: The fine structure and function of the injured lymphatic capillary after injection of saline solution. 3rd International Congress of Lymphology, Belgium, 1970.Google Scholar
  2. 2.
    Seiji, M., Shimao, K., Birbeck, M.S.C. and Fitzpatrick, T.B.: Subcellular localization of melanin biosyntheais. Annals of N.Y. Academy of Sciences, 100: 497, 1963.Google Scholar
  3. 3.
    Ohkuma, M.: Fine Structure and function of cutaneous and renal lymphatic capillary. Bullentin Tokyo Med. & Dent. Univ., 17: 103, 1970.Google Scholar
  4. 4.
    Leak, L.V. and Burke, J.F.: Electron microscopic study of lymphatic capillaries in the removal of connective tissue fluids and particulate substances. Lymphology, 1: 39, 1968.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Moriya Ohkuma
    • 1
  1. 1.Electron Microscopic Laboratory, Department of DermatologyTokyo Medical and Dental University YushimaTokyoJapan

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