Liposome Targeting to Tumor Cells in Vivo

  • D. Papahadjopoulos
  • A. Gabizon
Part of the NATO ASI Series book series (NSSA, volume 199)


Considerable effort has been mounted both in our own and other laboratories in order to enhance the ability of liposomes to deliver drugs to specific cells. This effort resulted in the development of methods for conjugation of antibodies on the liposome surface (Heath et al, 1980; Leserman et al, 1980; Huang et al, 1980), temperature-sensitive liposomes (Papahadjopoulos et al, 1973; Yatvin et al, 1978) which can be used in conjunction with hyperthermia (Weinstein et al, 1979) and pH-sensitive liposomes, either for localization of drugs in low pH areas (Yatvin et al, 1980) or for release of the liposome-encapsulated drugs following endocytosis (Dusgunes et al, 1985; Ellens et al, 1984; Connor et al, 1984).


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • D. Papahadjopoulos
    • 1
  • A. Gabizon
    • 1
    • 2
  1. 1.Cancer Research Institute and Department of PharmacologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Liposome Technology, Inc.Menlo ParkUSA

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