Endocytosis of Cell Surface Molecules and Intracellular Delivery of Materials Encapsulated in Targeted Liposomes
The principle benefits for pharmacologic purposes of liposomes include the possibility of transporting highly concentrated reagents entrapped in the liposomes’ aqueous spaces or lipid bilayer and their protection against enzymatic degradation. In addition, certain molecules which may have little or no capacity to enter into cells because of their size or charge may be delivered in biologically active form inside cells by virtue of their association with liposomes. This capacity is enhanced when liposomes are targeted to the cell surface by the use of specific ligands such as monoclonal antibodies, which may additionally offer the possibility to concentrate material at the cell surface and to target sub-populations in a heterogeneous mixture of cells (for reviews see Leserman and Machy, 1987; Ostro, 1987).
KeywordsAcidity Interferon Enzymatic Degradation Half Life Methotrexate
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