Modeling of Cell Membrane Targeting: Specific Recognition, Binding, and Protein Domain Formation in Ligand-Containing Model Biomembranes
Drug delivery systems are designed to assist, accelerate, and control transport of pharmacologically active agents from sites of administration to specified targets in organs and tissues. So-called controlled drug delivery systems are intended to maintain continuously efficacious drug concentrations in vivo, either locally or systemically, over longer time periods. They should provide constant dosage levels above a minimum level of efficacy yet below mandated toxicity levels — a significant advantage over many conventional systemically administered formulations. Site-specific targeting of drugs, particularly those agents which prove highly toxic in small doses, can be utilized to maintain therapeutically relevant levels of drug to targeted tissue at a localized site specifically without systemic toxicity. Pharmaceutical problems, such as avoidance of first-pass effects in the liver, spleen, and filtration organs, solubility and stability problems in certain formulations, as well as the reliability of long-term delivery within a single device are important advantages in clinical applications of controlled and targeted drug delivery systems.
KeywordsDomain Formation Lipid Monolayer Phase Transition Region Phospholipid Monolayer Enzyme Domain
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