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Targeting of Drugs 2 pp 21–27Cite as

Recombinant Ligand-Toxin Conjugates, Domain Engineering and the Search for Targeted Pharmaceuticals

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Part of the book series: NATO ASI Series ((NSSA,volume 199))

Abstract

Affinity therapy is the opportunity to attempt precise targeting of therapeutic effectors to their site of action. Within the past years, advances in biochemistry and molecular biology of membranes and cell growth regulation have provided tools that can assist in the design of more selective chemotherapeutic agents. Cloning and expressing genes coding for a variety of effector molecules allows the assembly of recombinant chimaeras for anticancer, immunosuppressive, antiviral and cardiovascular targeted therapy (Soria and Zeller, 1978; Soria and Martini, 1987; Soria, 1989a). Site-specific delivery might thus fulfil Paul Ehrlich’s dream of “magic bullets” by engineering specific structural/functional domains into therapeutic agents, in order to improve their persistence in the circulation and to localize them at the site of action.

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Author information

Authors and Affiliations

  1. Biotechnological Research, Farmitalia Carlo Erba, 24 Viale E. Bezzi, Milano, Italy

    Marco Soria

  2. Institute of Pharmacological Sciences, University of Milano, Italy

    Marco Soria

Authors
  1. Marco Soria
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Editor information

Editors and Affiliations

  1. School of Pharmacy, University of London, London, UK

    Gregory Gregoriadis

  2. Syntex Research, Palo Alto, California, USA

    Anthony C. Allison

  3. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA

    George Poste

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© 1990 Plenum Press, New York

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Soria, M. (1990). Recombinant Ligand-Toxin Conjugates, Domain Engineering and the Search for Targeted Pharmaceuticals. In: Gregoriadis, G., Allison, A.C., Poste, G. (eds) Targeting of Drugs 2. NATO ASI Series, vol 199. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-9001-5_2

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  • DOI: https://doi.org/10.1007/978-1-4684-9001-5_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-9003-9

  • Online ISBN: 978-1-4684-9001-5

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