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Controlled Delivery to the Brain

  • Henry Brem
Part of the NATO ASI Series book series (NSSA, volume 199)

Abstract

Controlled delivery of drugs directly to the site of a growing brain tumor has the potential to increase drug efficacy while reducing systemic side effects. Hochberg and Pruitt (1980) showed that 90% of malignant gliomas recur within a 2 cm margin of the original tumor. Thus, targeting therapy in this region holds the promise of controlling tumor growth and minimizing the systemic toxicity of the drugs. Localized, prolonged delivery of drugs to the brain is now possible by using polymeric delivery systems.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Henry Brem
    • 1
    • 2
  1. 1.Department of Neurological SurgeryJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Ophthalmology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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