Controlled Delivery to the Brain
Controlled delivery of drugs directly to the site of a growing brain tumor has the potential to increase drug efficacy while reducing systemic side effects. Hochberg and Pruitt (1980) showed that 90% of malignant gliomas recur within a 2 cm margin of the original tumor. Thus, targeting therapy in this region holds the promise of controlling tumor growth and minimizing the systemic toxicity of the drugs. Localized, prolonged delivery of drugs to the brain is now possible by using polymeric delivery systems.
Unable to display preview. Download preview PDF.
- Brem, H., Ahn, H., Tamargo, R.J., Pinn, M.L. and Chasin, M., 1988, A biodegradable polymer for intracranial drug delivery: A radiological study in primates. American Association of Neurological Surgeons, Toronto, p. 349.Google Scholar
- Brem, H., Tamargo, R.J. and Olivi, A., 1990, Delivery of drugs to the brain by use of a sustained release polymer system, to: “New Technologies and Concepts for Reducing Drug Toxicity”, H. Salem, ed., Telford Press, Caldwell, N.J., in press.Google Scholar
- Brem, H., Tamargo, R.J., Pinn, M. and Chasin, M., 1989, Biocompatibility of a BCNU-loaded biodegradable polymer: A toxicity study in primates. American Association of Neurological Surgeons, Toronto, p. 381.Google Scholar
- Chasin, M., Domb, A., Ron, E., Mathiowitz, E., Leong, K., Laurencin, C., Brem, H. and Langer, R., 1990, Polyanhydrides as drug delivery systems, to “Biodegradable Polymers as Drug Delivery Systems”, R. Langer and M. Chasin, eds.. Marcel Dekker toe.. New York, in pressGoogle Scholar
- Gimbrone, M.A., Cotran, R.S., Leapman, S.B. and Folkman, J., 1974, Tumorgrowth and neovascularization: An experimental model using the rabbit cornea,J.N.C.I., 52:413.Google Scholar
- Langer, R. and Wise, D., eds., 1986, “Medical Applications of Controlled Release”, Vols. I and II, CRC Press, Boca Raton, Florida.Google Scholar
- Rosenblum, M.L., Bowie, D.L. and Walker, M.D., 1973, Diffusionin vitroandin vivoof 1- (2-chloroethyl) -3- (trans-4-methylcyclohexyl)-1-nitro- sourea from silicone rubber capsules: A potentially new mode of chemotherapy administration.Cancer Res., 33:906.Google Scholar
- Tamargo, R.J., Epstein, J.I., Reinhard, C.S., Chasin, M. and Brem, H., 1988, Brain biocompatibility of a biodegradable polymer capable of sustained release of macromolecules, American Association of Neurological Surgeons, Toronto, p. 399.Google Scholar
- Tamargo, R.J., Mtyseros, J.S. and Brem, H., 1988, Growth inhibition of the 9L gliosarcoma by the local sustained release of BCNU: a canparison of systemic versus regional chemotherapy, American Association of Neurological Surgeons, Toronto, p. 212.Google Scholar
- Weiss, S.R. and Raskind, R., 1969, Treatment of malignant brain tumors by local methotrexate.International Smrg., 51:149.Google Scholar