Controlled Delivery to the Brain
Controlled delivery of drugs directly to the site of a growing brain tumor has the potential to increase drug efficacy while reducing systemic side effects. Hochberg and Pruitt (1980) showed that 90% of malignant gliomas recur within a 2 cm margin of the original tumor. Thus, targeting therapy in this region holds the promise of controlling tumor growth and minimizing the systemic toxicity of the drugs. Localized, prolonged delivery of drugs to the brain is now possible by using polymeric delivery systems.
KeywordsMalignant Glioma Malignant Brain Tumor Intermittent Infusion Rabbit Brain Monkey Brain
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