Targeted Therapy of Liver Carcinoma

  • N. I. Markham
  • J. R. Novell
Part of the NATO ASI Series book series (NSSA, volume 199)


This chapter is concerned with the clinical aspects of anti-cancer drug targeting with respect to liver tumours.


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  1. Ariel, I.M., 1965, Treatment of inoperable primary pancreatic and liver cancer by the intra-arterial administration of radioactive isotopes (Y-90 radiating microspheres), Ann.Surg., 162:267.CrossRefGoogle Scholar
  2. Bretagne, J., Raoul, J., Bourguet, P., Davauferrier, R., Deugnier, Y., Faroux, R., Ramee, A., Herry, J-Y. and Gastard, J., 1988, Hepatic artery injection of 1–131-labelled Lipiodol. Part II: Preliminary results of therapeutic use in patients with hepatocellular carcinoma and liver metastases. Radiology, 168:547.CrossRefGoogle Scholar
  3. Burnett, R.A., Patrick, R.S. and Spilg, W.C.S., 1978, Hepatocelluar carcinoma and hepatic cirrhosis in the west of Scotland: a 25 year necropsy review, J.Clin.Pathol., 31:108CrossRefGoogle Scholar
  4. Epirubicin study group for hepatocellular carcinoma. Intra-arterial administration of epirubicin in the treatment of nonresectable hepatocellular carcinoma, Cancer Chemother. Pharmocol., 19:183, 1987.Google Scholar
  5. Gilbert, J.C., Onik, G.M., Hoddick, W.K. and Rubinski, B., 1985, Real time ultrasonic monitoring of hepatic cryosurgery, Cryobiology. 22:319.CrossRefGoogle Scholar
  6. Hayashi, N., Yamamoto, K., Tamaki, N., Shibata, T., Itoh, K., Fujisawa, I., Nakano, Y., Yamaoka, Y., Kobayashi, N., Mori, K., Ozawa, K. and Torizuka, K., 1987, Metastatic nodules of hepatocellular carcincMna: detection with angiography, CT, and US, Radiology, 165:61.CrossRefGoogle Scholar
  7. Hochster, H.S., Green, M.D., Speyer, J., Fazzini, E., Blum, R. and Maggia, F.M., 1985, 4’epidoxorubicin (Epirubicin): activity in hepatocellular carcinana, J.Clin.Oncol., 3:1535.CrossRefGoogle Scholar
  8. Iwai, K., Maeda, H. and Konno, T., 1984, Use of oily contrast medium for selective drug targeting to tumour: enhanced therapeutic effect and X-ray image. Cancer Res., 44:2115.PubMedGoogle Scholar
  9. Iwai, K., Maeda, H., Koimo, T., Matsumara, Y., Yamashita, R., Yamasaki, K., Hirayama, S. and Miyauchi, Y., 1987, Tumour targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver, Anticancer Res., 7:321.PubMedGoogle Scholar
  10. Johnson, P.J., Williams, R., Thomas, H., Sherlock, S. and Murray-Lyon, I.M., 1978, Induction of remission in hepatocelliilar carcinoma with doxorubicin, Lancet, i:1007.Google Scholar
  11. Kobayashi, H., Shimida, H., Yano, T., Maeda, T., Oyama, T. and Shinohara, S., 1987, Intra-arterial injection of adriamycin/mitomycin C Lipiodol suspension in liver metastases. Acta Radiolog., 28:275.Google Scholar
  12. Kohler, G. and MLlstein, C., 1975, Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256:495.CrossRefGoogle Scholar
  13. Konno, T., Maeda, H., Iwai, K., Tashiro, S., Maki, S., Morinaga, T., Mochinaga, M., Hiraoka, T. and Yokoyama, I., 1983, Effect of arterial administration of higji-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report, Eur.J.Cancer Clin.Oncol.,19:1053.CrossRefGoogle Scholar
  14. Uvraghi, T., Salmi, A., Bolondi, L., Marin, G., Arienti, V., Monti, F. and Vettori, C., 1988, Small hepatocellular carcinoma: percutaneous alcohol injection — results in 23 patients. Radiology, 168:313.CrossRefGoogle Scholar
  15. Mach, J-P., Buchegger, F., Fomi, M., Ritschard, J., Berchie, C., Lumbroso, J-D., Schreyer, M., Giradet, C., Accolla, R.S. and Carrel, S., 1981, Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tcxnoscintiscanning, Immunol.Today, 2:239.CrossRefGoogle Scholar
  16. Markham, N., Ritson, A., James, O., Curtin, N., Bassendine, M. and Sikora, K., 1986, Primary hepatocellular carcinoma localised by a radio- labelled monoclonal antibody, J.Hepatol., 2:25.CrossRefGoogle Scholar
  17. Markham, N.I. and Hobbs, K.E.F., 1988, Selective destruction of malignant hepatic tumours — the magic bullet approaches? J.Roy.Coll.Surg.E., 33:205.Google Scholar
  18. Miller, D.L., O’Leary, T.J. and Girton, M., 1987, Distribution of iodized oil within the liver after hepatic arterial injection. Radiology, 162:849.CrossRefGoogle Scholar
  19. Nakakuma, K. Tashiro, S., Uemura, K., Konno, T., Tanaka, M. and Yokoyama, I., 1979, Studies on the anticancer treatment with oily anticancer drug injected into the ligated hepatic artery for liver cancer. (Preliminary report) (in Japanese), Nichidoku Iho, 24(4):675.Google Scholar
  20. Ohishi, H., Uchida, H., Yoshimura, H., Ohue, S., Ueda, J., Katsuragi, M., Matsuo, N. and Hosogi, Y., 1985, Hepatocellular carcinoma detected by iodized oil; use of anticancer agents. Radiology, 154:25.CrossRefGoogle Scholar
  21. Old, L.J., 1981, Cancer immunology: the search for specificity. Cancer Res., 41:361.PubMedGoogle Scholar
  22. Order, S.E., Stillwagon, G.B., Klein, J.L., Leichner, P.K., Siegelman, S.S., Fishman, E.K., Ettinger, D.S., Haulk, T., Kopher, K. and Finney, K., 1985, Iodine 131 antiferritin, a new treatment modality in hepatoma: a radiation therapy oncology group study, J.Clin.Oncol., 3:1573.CrossRefGoogle Scholar
  23. Order, S.E., Vriesendorp, H.M., Klein, J.L. and Leichner, P.K., 1988, A phase I study of Yttrium-90 antiferritin: dose escalation and tumour dose. Antibody, Immunoconj.& Radiopharm., 1:163.Google Scholar
  24. Park, C.H., Siih, J.H., Yoo, H.S., Lee, J.T., Kim, D.I. and Kim, B.S., 1987, Treatment of hepatocellular carcinoma (HCC) with radiolabelled Lipiodol: a preliminary report, Nucl.Med.Comniun., 8:1075.CrossRefGoogle Scholar
  25. Peters, R.L., Afroudakis, A.P. and Tatler, D., 1977, The changing incidence of association of hepatitis B with hepatocellular carcincxna in California, Am. J.Clin.Pathol., 68:1.CrossRefGoogle Scholar
  26. Raoul, J., Bourguet, P., Bretagne, J., Duvauferrier, R., Coomaert, S., Damault, P., Ramee, A., Herry, J-Y. and Gastard, J., 1988, Hepatic artery injection of I-131-labelled Lipiodol. Part I: Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology, 168:541.CrossRefGoogle Scholar
  27. Sherlock, S., 1985, “Diseases of the liver and biliary system”, 7th edition, Oxford:Blackwell.Google Scholar
  28. Sikora, K., Alderson, T., Nethersell, A. and Snedley, H., 1985, Tumour localisation by human monoclonal antibodies, Med.Ocol& Tumor Hiarmacother., 2:77.Google Scholar
  29. Sitzmann, J.V., Order, S.E., Klein, J.L., Leichner, P.K., Fishman, E.K. and Smith, G.W., 1987, Conversion by new treatment modalities of non- resectable to resectable hepatocellular cancer, J.Clin.Oncol., 5:1566.CrossRefGoogle Scholar
  30. Tashiro, S and Maeda, H., 1985, Clinical evaluation of arterial administration of SMANCS in oily contrast medium for liver cancer, Jap.J.Med., 24:79.CrossRefGoogle Scholar
  31. Tsai, C., Kusumoto, Y., Harada, R., Shima, M., Nakata, K., Konno, K., Sato, A., Ishii, N., Koji, T. and Nagataki, S., 1986, Effect of intrahepatic arterial infusion of I-131-labelled Lipiodol on hepatocellular carcinoma of rat, Ann.Acad.Med.Singapore, 15:521.PubMedGoogle Scholar
  32. Wheeler, P.G., Melia, W., Dubbins, P., Jones, B., Niinnerley, H., Johnson, P. and Williams, R., 1979, Non-operative arterial embolisation in primary liver tumours, Br.Med.J., 2:242.CrossRefGoogle Scholar
  33. Zhang, X.F., Klein, J.L. and Order, S.E., 1988, Quantitative comparison of tumour dose of radiolabelled monoclonal and polyclonal antibodies in an experimental tumour model, Antibody, Immunoconj.& Radiopharm., 1:35.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • N. I. Markham
    • 1
  • J. R. Novell
    • 1
  1. 1.Academic Department of SurgeryRoyal Free HospitalLondonUK

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