The Analysis of Bordetella Pertussis Fimbrial Mutants in a Rabbit Model

  • Frits R. Mooi
  • Han G. J. van der Heide
  • Henk C. Walvoort
  • Henk Brunings
  • Wim H. Jansen
  • Piet A. M. Guinee
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 51)


Bordetella pertussis is the causative agent of whooping cough or pertussis, a serious respiratory disease (see ref. 1 for an excellent review). The first step in the pathogenesis of pertussis is adherence of the bacteria to the respiratory tract, and two classes of bacterial proteins are probably involved in this process, filamentous hemagglutinin (FHA), and fimbriae. After adherence, the bacteria proliferate and produce a number of toxins: tracheal cytotoxin, dermonecrotic toxin, adenyl cyclase and pertussis toxin. These toxins cause local tissue damage, immune suppression, and are responsible for the systemic effects of the disease. It has been suggested that pertussis toxin may also function as a colonization factor, since it is able to bind to both the bacteria and the host-cells (1).


Pertussis Toxin Pertussis Vaccine Bordetella Pertussis Whooping Cough Putative Promoter Region 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Frits R. Mooi
    • 1
  • Han G. J. van der Heide
    • 1
  • Henk C. Walvoort
    • 1
    • 2
  • Henk Brunings
    • 1
  • Wim H. Jansen
    • 1
  • Piet A. M. Guinee
    • 1
  1. 1.Department of BacteriologyNational Institute of Health and Environmental ProtectionBilthovenThe Netherlands
  2. 2.Department of Control of Bacterial VaccinesNational Institute of Health and Environmental ProtectionBilthovenThe Netherlands

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